JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Inhibitory effects of lead-excretion glycan on genetoxic and reproduction toxicity induced by lead in mice

ZHAO Hui-juan, LIU Ping, ZHUO Jin-hua, FENG Guo-chang   

  1. Department of Chemistry and Microbacteria Detection, School of Public Health, Shandong University, Jinan 250012, China
  • Received:2007-09-11 Revised:1900-01-01 Online:2008-06-16 Published:2008-06-16
  • Contact: LIU Ping

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Abstract: To study the influence of lead-excretion glycan on micronuclei formation in bone marrow and peripheral blood polychromatic erythrocyte (PCE) and on sperm abnormalities induced by lead in mice. Methods The KM strain mice were randomly divided into the negative control group, the positive control group, the lead control group, the high dosage group, the middle dosage group, the low dosage group and the preventative group based on body weight. The mice were given lead acetate by intraperitoneal injection and treated with lead-excretion glycan by intragastric administration. Micronucleus tests and sperm aberration tests were used． Results The micronuclei formation in bone marrow and peripheral blood PCE of the high and middle dosage groups were significantly less than that of the lead control group（P＜0.05）. The sperm abnormality rate of the high and middle dosage groups and the preventative group was significantly lower than that of the lead control group（P＜0.001）. Conclusion Leadexcretion glycan can to some extent inhibit the increase of micronuclei formation in bone marrow and peripheral blood PCE and sperm abnormalities in leadexposed mice.

Key words: Lead-excretion glycan, Lead, Mouse, Sperm abnormalities, Micronuclei

CLC Number: 

  • R155.33
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