Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (2): 27-31.doi: 10.6040/j.issn.1671-7554.0.2021.1307

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Expression and significance of poly(ADP-ribose) polymerase-1 in endometriosis

LIN Xueyan1, ZHANG Cancan2, TIAN Minle3, TIAN Yongjie1,4   

  1. 1. Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong Frist Medical University, Jinan 250021, Shandong, China;
    2. Department of Gynecology, Shandong Provincial Maternal and Child Health Care Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250014, Shandong, China;
    3. School of Basic Medicine, Shandong First Medical University, Jinan 250118, Shandong, China;
    4. Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong, China
  • Published:2022-01-25

Abstract: Objective To detect the expression of poly(ADP-ribose)polymerase-1(PARP-1)in eutopic and ectopic endometria of women with endometriosis, and to explore the correlation among PARP-1, E-cadherin, vimentin and Snail in eutopic and ectopic endometria of women with endometriosis. Methods The expressions of PARP-1, E-cadherin, Vimentin and Snail were detected with immunohistochemistry in eutopic and ectopic endometria of women with endometriosis, and in eutopic endometria of women without endometriosis. The correlation among their expressions was determined with Spearman analysis. Results The expressions of PARP-1, vimentin and Snail significantly increased in eutopic and ectopic endometria of women with endometriosis than in endometria of women without endometriosis(P<0.001), while the expression of E-cadherin significantly decreased(P<0.001). In eutopic endometria of endometriosis, the expression of PARP-1 was negatively correlated with E-cadherin(r=-0.39), but positively correlated with the expressions of vimentin and Snail(r=0.45 and 0.44, respectively); in ectopic endometria of endometriosis, the expression of PARP-1 was negatively correlated with E-cadherin(r=-0.41), but positively correlated with the expressions of vimentin and Snail(r=0.48 and 0.56, respectively). Conclusion PARP-1 is highly expressed in eutopic and ectopic endometria of women with endometriosis, PARP-1 may be involved in the epithelial mesenchymal transformation of endometriosis.

Key words: Poly(ADP-ribose)polymerase-1, Endometriosis, Epithelial mesenchymal transformation, E-cadherin protein, Snail protein

CLC Number: 

  • R711.71
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