Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (6): 33-39.doi: 10.6040/j.issn.1671-7554.0.2019.521

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Research advances in the pathogenesis of endometriosis

WANG Guoyun, YUAN Ming, JI Miaomiao   

  1. Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China)Abstract: Endometriosis(EMs)is a common gynecological disease with a prevalence of 10% in women of childbearing age. The main symptoms of EMs are pain and infertility, which seriously affect patients quality of life. However, 〓山〓东〓大〓学〓学〓报〓(医〓学〓版)57卷6期〓-王国云, 等.子宫内膜异位症发病机制研究进展〓\=-
  • Published:2022-09-27

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Abstract: Endometriosis(EMs)is a common gynecological disease with a prevalence of 10% in women of childbearing age. The main symptoms of EMs are pain and infertility, which seriously affect patients quality of life. However, 山 东 大 学 学 报 (医 学 版)57卷6期 -王国云,等.子宫内膜异位症发病机制研究进展 \=- there is no EMs-specific, non-invasive diagnostic method yet. Currently, EMs is treated with surgery or hormonoth-erapy, both of which have side effects and high recurrence rate. The ambiguity of EMs pathogenesis limits the diagnosis and treatment. The mainstream theory is retrograde menstruation, but the latest research shows that EMS is a complex chronic disease, which may be induced by the menstrual blood flow, while the complex interaction between genetic, immune and environmental factors plays a more important role. This paper will review the pathogenesis theories and latest research advances, especially the new research fields of EMs, and propose the problems in the EMs mechanism research.

Key words: Endometriosis, Gene, Immunity, Gut microbiota, Exosome

CLC Number: 

  • R711.71
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