Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (11): 113-120.doi: 10.6040/j.issn.1671-7554.0.2022.0357

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Time distribution and influencing factors of hepatitis B vaccine birth dose in 1,614 newborns of HBsAg positive women, Jinan City

ZOU Liping1, HE Yujing1, XIE Yuanzhong2, ZHAO Jianyun1, XU Chunhua1, MA Yongsheng1, LI Chuanbin1, LIU Xiaoxue1, LIU Chong3, ZHAO Xiaodong1, SUN Hongyun1   

  1. 1. Department of Expanded Program of Immunization, Jinan Center for Disease Control and Prevention, Jinan 250021, Shandong, China;
    2. Department of Expanded Program of Immunization, Pingyin Center for Disease Control and Prevention, Pingyin 250499, Shandong, China;
    3. Jinan Health Care Development Center, Jinan 250002, Shandong, China
  • Online:2022-11-10 Published:2022-11-04

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Abstract: Objective To investigate the time distribution of the birth dose of hepatitis B(HepB)vaccine in newborns of HBsAg-positive mothers in Jinan, and to evaluate possible problems and difficulties of hospitals in implementing the scheme. Methods Descriptive analysis was applied to describe general information and distribution of birth dose of HepB vaccine. Chi-square test and binary Logistic regression were used to analyze influencing factors. Qualitative field interview materials were analyzed and summarized with subject frame method to investigate the status and problems of current implementation practice. Results In 2020, 1,614 HBsAg positive pregnant women were hospitalized and gave birth at hospital. The rate of HepB vaccine birth dose within 24 hours and 12 hours were 98.76% and 78.81%, respectively. Newborns born at 8-11 and 14-16 oclock had the highest timely vaccination rate. Natural birth(OR=2.083), low birth weight(OR=2.793), birth time at night(OR=1.260)and first birth(OR=1.515)were risk factors affecting timely vaccination(all P<0.05). Qualitative interviews found that personnel and training needs increased after stricter time limit was issued. Conclusion The timely vaccination rate of HepB birth dose among infants of HBsAg positive women was high in 2020 in Jinan. Newborns delivered by caesarean section, with non-low birth weight, non-first-born and born before the peak time of obstetrical vaccination are more likely to be vaccinated in time. Personnel and training needs are the main concerns after stricter time limit is issued. It is suggested to strengthen the training of medical personnel and arrange the vaccination shifts reasonably in order to improve the timely vaccination rate.

Key words: HBsAg positive, Newborns, Hepatitis B vaccine, Birth dose, Influencing factors

CLC Number: 

  • R186
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