Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (7): 68-73.doi: 10.6040/j.issn.1671-7554.0.2021.0038

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Diagnostic value of contrast-enhanced endoscopic ultrasonography combined with endoscopic ultrasound-guided fine needle aspiration for pancreatic masses

CHEN Gang, ZHANG Yanping, YE Leping, FU Chong, ZHOU Chunyan, ZHANG Shidong   

  1. Department of Gastroenterology, Anqing Hospital Affiliated to Anhui Medical University, Anqing 246000, Anhui, China
  • Published:2021-07-16

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Abstract: Objective To explore the diagnostic value of contrast-enhanced endoscopic ultrasonography(CE-EUS)combined with endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)for pancreatic cancer. Methods The clinical data of 175 patients with pancreatic space-occupying lesions treated during Jan. 2017 and Dec. 2020 were retrospectively analyzed. Based on the results of surgery and puncture pathology or follow-up data, 132 patients met the inclusion requirements, including 55 patients who received enhanced CT and/or enhanced MRI, 40 patients who received EUS examination, and 37 patients who received CE-EUS combined with EUS-FNA. The value of the three methods in the diagnosis of pancreatic masses were compared. Results The results of enhanced CT and/or enhanced MRI showed 13 benign cases and 42 malignant cases. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 79.49%(31/39), 56.25%(9/16), 81.58%(31/38), 52.94%(9/17), and 72.73%(40/55), respectively. EUS showed 13 benign cases and 27 malignant cases. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 80.00%(24/30), 60.00%(6/10), 85.71%(24/28), 50.00%(6/12), and 75.00%(30/40), respectively. CE-EUS combined with EUS-FNA showed 14 benign cases and 23 malignant cases. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 93.94%(31/33), 75.00%(3/4), 96.87%(31/32), 60.00%(3/5), and 91.89%(34/37), respectively. Pancreatic masses showed uneven spots or rod-like low enhancement mode under CE-EUS, and FNA in the low enhancement area could improve the positive rate of puncture. Conclusion CE-EUS combined with EUS-FNA can improve the diagnostic accuracy of pancreatic masses, which is worthy of clinical promotion.

Key words: Contrast enhancement, Endoscopic ultrasonography, Fine needle aspiration, Pancreatic mass, Diagnosis

CLC Number: 

  • R576
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