JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (1): 60-62.doi: 10.6040/j.issn.1671-7554.0.2016.1534

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Effects of female age on the outcome of preimplantation genetic diagnosis and screening

LI Yun, ZHONG Wanxia, YAO Ning, HU Shuanggang, LIU Hongmao   

  1. Center for Reproductive Medicine, Renji Hospital, Medical School of Shanghai Jiaotong University;
    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China
  • Received:2016-11-20 Online:2017-01-10 Published:2017-01-10

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Abstract: Objective To investigate the female effects of age on the outcome of preimplantation genetic diagnosis and screening(PGD/PGS). Methods Clinical data of 149 patients who received PGD/PGS in our hospital during Jan. and Dec. 2015 were retrospectively reviewed. The patients were divided into 3 groups according to age: group Ⅰ(n=10, <25 years, 36 blastocysts), group Ⅱ(n=94, 25-34 years, 329 blastocysts), and group Ⅲ(n=45, ≥35 years, 89 blastocysts). The normal chromosome rate and clinical pregnancy rate of the three groups were compared. Results The normal chromosome rate in groups Ⅰ, Ⅱ and Ⅲ was 50.00%, 50.15% and 29.21%, respectively. There were statistical differences between groups Ⅰ and Ⅲ(χ=24.855, P<0.05), and groups Ⅱ and Ⅲ(χ=212.376, P<0.05). The clinical pregnancy rate in groups Ⅰ, Ⅱ and Ⅲ was 82.33%, 82.50% and 40.00%, respectively. There were statistical differences between groups Ⅰ and Ⅲ(χ=23.893, P<0.05), and groups Ⅱ and Ⅲ(χ=27.510, P<0.05). Conclusion The female age can affect the outcome of PGD/PGS. Age ≥35 years will significantly reduces the normal chromosome rate and clinical pregnancy rate.

Key words: Female age, Normal chromosome rate, Blastocyst biopsy, Clinical pregnancy rate, Preimplantation genetic diagnosis and screening

CLC Number: 

  • R715.5
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