Abstract: Objective To explore the effects of post-conditioning with nicorandil on myocardial, cerebral and renal ischemia-reperfusion injury following cardiac arrest in a porcine. Methods A total of 22 landrace pigs were randomized into the sham group(n=4)and resuscitation group(n=18). The resuscitation group received ventricular fibrillation induced by electrical stimulation for 4 min and then cardiopulmonary resuscitation. The sham group received surgery only. The resuscitation group was subdivided into saline control group(n=8)and nicorandil(n=8)group. The nicorandil group was given central intravenous injection of nicorandil(150 μg/kg)at onset of restoration of spontaneous circulation(ROSC), followed by 3 μg/(kg·min)intravenous drip until the end of reperfusion. The saline control group was given the same dosage of saline. At baseline, 5 min, 30 min, 3 h and 6 h after ROSC, blood samples were collected to examine the level of cardiac troponin I(cTnI). At 6 h after ROSC, the cardiac apex, parietal-cerebral cortex and upper pole of left kidney were removed for microstructure and ultrastracture studies. Results The cTnI level was significantly 山 东 大 学 学 报 (医 学 版)55卷10期 -梁丽宁,等.尼可地尔后适应对猪心脏骤停后心脑肾缺血再灌注损伤的保护作用 \=-increased in the resuscitation group than in the sham group after ROSC(P<0.05). The cTnI level was significantly decreased in the nicorandil group than in the saline control group(P<0.05). Histopathologic injury was relieved in the nicorandil group. Conclusion Post-conditioning with nicorandil can relieve myocardial, cerebral and renal ischemia-reperfusion injury following cardiac arrest in swine.

Key words: Ischemia-reperfusion injury, Heart, Swine, Nicorandil, Cardiac arrest, Brain, Kidney