JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (4): 1-5.doi: 10.6040/j.issn.1671-7554.0.2015.1097

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Role of liraglutide in the repair of spinal cord injury

LI Hongzhi1,2, LIU Jing3, SONG Yan1,2, CHI Lingyi1,2, LIU Yuguang1,2   

  1. 1. Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Brain Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Department of Anesthesia, Taian Central Hospital, Taian 271000, Shandong, China
  • Received:2015-11-26 Online:2016-04-10 Published:2016-04-10

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Abstract: Objective To investigate the role and mechanism of liraglutide in the repair of spinal cord injury(SCI)in rats. Methods A total of 48 rat models of clip compressive SCI were established and then divided into 2 groups: liraglutide treatment group(n=24)and normal control group(n=24), which were injected with liraglutide(0.12 mg/kg, 0.5 mL)and physiological saline(0.5 mL)respectively after the operation. The apoptosis of neurocytes was detected with TUNEL method on day 2 after operation, the expressions of interleukin-1β and interleukin-6 were detected with Western blotting protein imprinting technology on day 3, the structure of injured spinal cord tissue was observed with HE staining on day 14, and the BBB score of hind limbs of rats behavior were recorded from day 3 to day 28. Results The rate of cell apoptosis, expression of inflammatory factors, and cavity area of the liraglutide treatment group were lower than those of the control group(all P<0.05), while the BBB scores of both hind limbs were higher than those in the control group at the same period(P<0.05). Conclusion Liraglutide treatment after spinal cord injury may reduce cell apoptosis acute inflammation, and is conducive to the late repair of nerve cells and the recovery of motor function.

Key words: Spinal cord injury, Liraglutide, Cell apoptosis, Interleukin-1β, Interleukin- 6, Inflammation, Rats

CLC Number: 

  • R574
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