JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (6): 7-11.doi: 10.6040/j.issn.1671-7554.0.2015.341

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Study of mouse alveolar bone defect reparation by dialdehyde bletilla striata glucomanna / hydroxypropyl chitosan / nano-nacre powder composited scaffolds

CHEN Yihui1, LIU Xuewei1, HOU Xuhao2, SUN Qinfeng1   

  1. 1. Department of Periodontics, School of Stomatology, Shandong University, Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012, Shandong, China;
    2. School of Pharmacy, Shandong University of Chinese Traditional Medicine, Jinan 250355, Shandong, China
  • Received:2015-04-01 Online:2016-06-20 Published:2016-06-20

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Abstract: Objective To observe the osteogenesis and degradation of dialdehyde letilla striata glucomanna(DBsGM)/hydroxypropyl chitosan(HPCS)/nano-nacre powder(NNP)composited scaffolds in rat alveolar bone defect regeneration. Methods A total of 32 male Wistar rats with bilateral mandibular molar area box defects were randomly divided into 4 groups according to the disposal time(week 2, 4, 6, 8), with 8 animals in each group. The DBsGM/HPCS/NNP composited scaffolds were implanted in the experimental side, while nothing was implanted in the control side. The bone defect repair effect was evaluated with hematoxylin-eosin staining and histologic measurement. Results As time extended, the percentage of new bone area increased gradually, and there was significant difference between different time points(P<0.05). At the same time point, the experimental group was superior to the control group in gross observation and histological observation(P<0.05). The implanted materials gradually degraded with time. During week 6 to 8, the implanted materials completely degraded. Conclusion DBsGM/HPCS/NNP composited scaffolds can promote rat alveolar bone defect repair and regeneration.

Key words: Tissue engineering, Periodontal tissue regeneration, Nano-nacre powder, Bletilla striata glucomannan, Periodontal defects in rats

CLC Number: 

  • R781
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