JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (3): 40-44.doi: 10.6040/j.issn.1671-7554.0.2013.527

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Experimental study of the bletilla striata glucomanan composited scaffolds by orthogonal experiment

LIU Xuewei1, HOU Xuhao2, CHEN Yihui1, SUN Qinfeng1, PENG Fengmei3   

  1. 1. Department of Periodontics, School of Stomatology, Shandong University;
     Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012, Shandong, China;
    2. School of Pharmacy, Shandong University of Chinese Traditional Medicine, Jinan 250355, Shandong, China;
    3. Department of Dentistry, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2013-08-30 Online:2014-03-10 Published:2014-03-10

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Abstract:

Objective  To study the preparation of bletilla striata glucomanan composited scaffolds used for bone tissue regeneration and to analyze its optimum proportion by orthogonal experiment. Methods  Bletilla striata glucomannan was oxidized by sodium periodate, mixed with hydroxypropyl chitosan and nano-nacre powder, and then the scaffold was created by freeze-dry method, and its properties were tested. Results  Bletilla striata glucomanan composited scaffolds was synthesized and optimized. All its properties met the requirements of tissue engineering. Conclusion  This study optimized Bletilla striata glucomanan composited scaffolds successfully by orthogonal experiment. It provided a theoretical basis for further research on the scaffold, which may become a new material for bone tissue regeneration.

Key words: Bletilla striata glucomannan, Tissue engineering, Nano-nacre powder, Hydroxypropyl chitosan

CLC Number: 

  • R781
[1] CHEN Yihui, LIU Xuewei, HOU Xuhao, SUN Qinfeng. Study of mouse alveolar bone defect reparation by dialdehyde bletilla striata glucomanna / hydroxypropyl chitosan / nano-nacre powder composited scaffolds [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 7-11.
[2] ZHAO Wenzhuo, FAN Tingjun, HU Xiuzhong, NIU Ying. In vitro reconstruction of tissue-engineered human corneal stroma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(8): 62-.
[3] JIANG Jinzhu1， WU Yan2， LU Qing1， JIA Jun1, SHAO Yang1， SONG Guodong1. Effect of matrix metalloproteinase-7 on immunogenicity of porcine acellular dermal matrix [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(8): 74-.
[4] ZHANG Shi-jie1，CHEN Fei1，JIANG XIN-quan2. Cell compatibility of a new type polyporous RGD-PLGA/HA scaffold in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(5): 29-33.
[5] LIN Zhi-yong,SHAN Xiu-li,WANG Qing. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(7): 666-670.
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