JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of different interventional modalities on expression of resistin in dietinduced hyperresistinemia in rats

LI Yan1,2, WANG Yi1, HUANG Lei2, AN Xiangmei2, ZHOU Yaping2
   

  1. (1. Department of Pediatrics, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China；
    2. Department of Pediatrics, Shandong Maternity and Child Care Institute, Jinan 250014, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-03-16 Published:2009-03-16
  • Contact: WANG Yi

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Abstract: To study the effect of different interventional modalities on expression of resistin in dietinduced hyperresistinemia in rats. MethodsSD rats were randomly divided into the control group and the highfat group and were fed with a basic and highfat diet respectively for 8 weeks. Rats with a higher resistin level than an x+2s level of resistin in the CO group were defined as dietinduced hyperresistinemia models. The dietinduced hyperresistinemia rats were randomly divided into the rosiglitazone group, the swimming group, the dietcontrol group and the hyperresistinemia group, which were respectively subjected to rosiglitazone in combination with dietcontrol intervention, swimming in combination with dietcontrol intervention, dietcontrol intervention and a highfat diet for 8 weeks. ResultsThe levels of resistin and insulin in the serum and expression of resistin in fat were decreased in the rosiglitazone group, the swimming group and the dietcontrol group. ConclusionExercise and dietcontrol could decrease expression of resistin in dietinduced hyperresistinemia.

Key words: Resistin, Insulin resistance, Exercise, Rosiglitazone, Rats

CLC Number: 

  • R725
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