JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Relationship between mesial temporal lobe epilepsy and human herpesvirus-6

YU Zhen, SUN Ruo-peng   

  1. Department of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2007-11-09 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: SUN Ruo-peng

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Abstract: To investigate the correlation between human herpesvirus-6 (HHV-6)infection and mesial temporal lobe epilepsy(MTLE). Methods27 patients with intractable epilepsy and 20 normal controls were determined HHV-6 using polymerase chain reaction(PCR). Of the 27 patients, 15 had MTLE and 12 did not. ResultsIn brain tissues, positive rates of HHV-6 in refractory epilepsy, MTLE, and nonMTLE groups were 44.4%, 66.7% and 16.7% respectively, and no positive cases were found in the control group. Also 11 positive hematological cases were found in the MTLE group, 3 in the nonMTLE group and 1 in the control group. ConclusionIntractable epilepsy, especially mesial temporal lobe epilepsy has a close relation ship to human herpesvirus-6.

Key words: Epilepsy, Herpesvirus 6, human, PCR

CLC Number: 

  • R725
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