JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Methylcyclopentadienyl manganese tricarbonyl injuries in PC-3M cells

QIN Wen1，WANG Li-xiang2，ZENG Ji-ping3，CHEN Wei-wen3，ZHANG Ya-lun3   

  1. 1. School of Public Health; 2. Institute of Phamocology, School of Medicine; 3. Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University
  • Received:2006-12-13 Revised:1900-01-01 Online:2007-07-24 Published:2007-07-24
  • Contact: ZENG Ji-ping

PDF (PC)

401

Abstract: Objective: To explore the effect of methylcyclopentadienyl manganese tricarbonyl (MMT) on PC-3M cells. Methods: The MTS method was used to determine the time and concentration curves induced by MMT on PC-3M cells. Spectrophotometry was used to determine the changes of ROS, LDH and MDA and the activity of SOD. Results: The survival viability of cells decreased with MMT in a dose-and concentration-dependent manner. After induction by 2mmol/L MMT for 24h, the survival rate of PC-3M cells was 48.55%（P＜0.01）. In this process, the ROS, LDH and MDA obviously increased（P＜0.01）, and the activity of SOD significantly decreased（P＜0.01）. Conclusion: MMT injures PC-3M cells.

Key words: MMT, Prostate, Injury

CLC Number: 

  • R994.6
[1] ZHANG Shi-Bao, LIU Qing-Yong, RUAN Xi-Yun, CHEN Jie, ZHANG Jian-Jun, LI Zong-Wu, YANG Guang-Xiao, WANG Quan-Ying. onstruction and identification of the expression vector of
NT4-SAC-HA2-TAT fusion gene [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 15-19.
[2] SUO Dongyang, SHEN Fei, GUO Hao, LIU Lichang, YANG Huimin, YANG Xiangdong. Expression and mechanism of Tim-3 in animal model of drug-induced acute kidney injury [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 1-6.
[3] LONG Tingting, XIE Ming, ZHOU Lu, ZHU Junde. Effect of Noggin protein on learning and memory abilities and the dentate gyrus structure after cerebral ischemia reperfusion injury in mice [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 15-23.
[4] DONG Wei, XING Naidong, LÜ Jiaju, LIU Shuai, SUN Liang, CAO Qingwei, DONG Yuhao, LIU Zhao, DING Sentai. The therapeutic efficacy of a potent KSP inhibitor S(MeO)TLC against docetaxel-resistant prostate cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 23-30.
[5] LIU Dong, ZHU Dongyun, PENG Changliang, ZHANG Cheng, ZHAO Jie, GAO Chunzheng. Construction and appraisal of hyaluronic acid hydrogel scaffold in the treatment of treat spinal cord injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 53-59.
[6] LIU Fang, QIAO Lei, CHEN Wenchao, YANG Lina. Cardioprotective effects of allicin postconditioning on myocardial ischemia-reperfusion injury in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 6-11.
[7] YIN Ni, YANG Guanlin, JIANG Junwen, WANG Chuntian, WANG Fengyao, JIA Lianqun, GAO Xiaoyu, PAN Jiaxiang, LI Qin, LI Jia, FENG Yuanjie, GAO Yuzhu, ZHOU He, ZHANG Zhe. A reliable system to assess atherosclerosis model of Bama minipigs [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 1-5.
[8] CUI Meng, ZHENG Jilu, TIAN Sinan, LI Lianjun, ZHANG Qi, JIN Xunbo, WANG Muwen. Photoselective vaporization of the prostate for the treatment of benign prostatic obstruction in patients with Parkinsons disease [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 100-102.
[9] CHEN Lei, LIU Dongxiao, LI Kaiming, SONG Xinqiang, ZENG Xiansi, JIANG Lijie. Uniaxial-channel collagen scaffolds loaded with CBD-BDNF improves the recovery of rat spinal cord injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 43-48.
[10] ZHANG Yu, HAN Chen, WANG Zhaoxia, WANG Zhaopeng, ZHANG Yueying, ZHOU Shuping, MA Ranran, WANG Hengxiao. Protective effects of Tamarix chinensis Lour on mice with alcoholic liver injury and its mechanism [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 61-67.
[11] LIANG Lining, ZHONG Xia, JI Xianfei, HU Haoran, ZHU Fangfang, CHEN Jibin,CHEN Qianqian, SHANG Deya. Protective effects of post-conditioning with nicorandil on myocardial, cerebral and renal ischemia-reperfusion injury following cardiac arrest in swine [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 46-51.
[12] XIA Chuanyou, LI Luchao, LI Xiaofeng, YAN Keqiang, ZHANG Nianzhao, FAN Yidong, LIU Cheng. Expression of histone methyltransferase SMYD3 in prostate cancer tissues and its role in mTOR pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(5): 12-16.
[13] LI Hongzhi, LIU Jing, SONG Yan, CHI Lingyi, LIU Yuguang. Role of liraglutide in the repair of spinal cord injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 1-5.
[14] LI Xin, WANG Gongming, WANG Hong, WANG Yan, ZHANG Ligong, ZHANG Le, LIU Bei, ZHANG Mengyuan. Inducible nitric oxide synthase contributes to the delayed cardioprotection of ischemic postconditioning in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 16-20.
[15] ZHAI Hongyun, ZHANG Denglu, WANG Guangjie, KONG Feng, CHENG Guanghui, ZHAO Shengtian. Effects of factors secreted by mouse embryonic stem cells on prostate cancer cells in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(9): 8-12.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd