JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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LIU Jian-jun, LI Zhen-zhong,JU Ying, LI Yong-gang,SHAO Feng,LIU Zhen,WANG Huai-jing1,XING Zi-ying   

  • Received:2005-06-06 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24
  • Contact: LIU Jian-jun

Abstract: To study the expression of cardiotrophin1 (CT1) in hypertrophic cardiac myocytes induced by high glucose and insulin, and the effect of pioglitazone on the expression of cardiotrophin1(CT1). Methods: The cardiac myocytes were cultured in vitro as a model. Cellular surface, protein content and atrial natriuretic factor mRNA were measured as the cellular hypertrophic parameters. Meanwhile, the expression of cardiotrophin1 mRNA was assayed with semiquantitative RTPCR. Results: After treatment with high glucose and insulin, cellular surface, protein content and expression of atrial natriuretic factor mRNA increased significantly　(P<0.01). Pioglitazone inhibited all these above effects effectively (P<0.05). Conclusion: The results suggest that cardiotrophi1 is involved in the development of myocardial hypertrophy induced by high glucose and insulin. And pioglitazonemay inhibit myocardial hypertrophy by restraining the expression of cardiotrophin1.

Key words: Pioglitazone, High glucose, High insulin, Cardiac hypertrophy, Cardiotrophin1, Rats, Wistar

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