Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (2): 118-124.doi: 10.6040/j.issn.1671-7554.0.2024.1140

• Review • Previous Articles    

Research progress on oxidative stress in acute lung injury induced by traumatic brain injury

LI Xiang, ZHANG Yi, WANG Xuechun, XU Mengchao, WANG Yuelan   

  1. Department of Anesthesiology, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong, China
  • Online:2025-03-10 Published:2025-03-07

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Abstract: Traumatic brain injury represents a significant global public health concern, with its associated acute lung injury gaining increased attention. The pathogenesis of acute lung injury induced by traumatic brain injury is complex, involving multiple factors and mechanisms. Effective management requires a comprehensive understanding of the interplay between traumatic brain injury and acute lung injury. This article summarizes recent advances in understanding how oxidative stress induces damage to the alveolar-capillary barrier, as well as its role in promoting pulmonary inflammation and exacerbating coagulation dysfunction in acute lung injury induced by traumatic brain injury. Additionally, it explores the potential therapeutic effects of agents such as dexmedetomidine, gastrin, polydatin, and enoxaparin, providing a foundation for future clinical strategies aimed at the prevention and treatment of acute lung injury induced by traumatic brain injury. These insights offer valuable theoretical guidance for clinicians in improving patient outcomes.

Key words: Traumatic brain injury, Acute lung injury, Oxidative stress, Alveolar-capillary barrier, Apoptosis

CLC Number: 

  • R563
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