Journal of Shandong University (Health Sciences) ›› 2026, Vol. 64 ›› Issue (2): 44-49.doi: 10.6040/j.issn.1671-7554.0.2024.0677

• Review • Previous Articles    

Research progress of antioxidant carbon dot nanozymes to regulate the neuro-regeneration microenvironment

YU Haozhi1, SHI Guidong1, XU Guopeng2, JIANG Yunpeng1, FENG Shiqing3, LIU Xinyu1, QI Lei1   

  1. 1. Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. School of Physics, Shandong University, Jinan 250100, Shandong, China;
    3. The Second Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2026-02-10

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Abstract: Carbon dot, as an emerging zero-dimensional photoluminescent nanomaterial, has broad application prospects in biomedicine, sensors, and optoelectronic devices due to their simple preparation, easy regulation of optical properties, high photochemical stability, excellent photoelectric properties, low toxicity, and good biocompatibility. With the research deepening, a variety of carbon dots have been successively reported to exhibit excellent enzyme-like catalytic activity(carbon dot nanozymes), and can be used to regulate the pathological redox microenvironment for efficient disease treatment. To elucidate the unique advantages and potential prospects of carbon dot nanozymes in neuroscience, in this review, we firstly introduced the antioxidant capacity and the activity source of carbon dots, and then discussed the antimicrobial activity and their corresponding action mechanisms. Finally, we summarized the recent progress of antioxidant carbon-dot nanozymes in regulating the neuro-regeneration microenvironment, and further proposed the prospect of carbon dot-based modulation of pathological microenvironment for nerve regeneration.

Key words: Carbon dot nanozymes, Central nervous system, Microenvironment, Neuro-regeneration, Oxidative stress

CLC Number: 

  • R681.5
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