Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (10): 27-33.doi: 10.6040/j.issn.1671-7554.0.2024.0936

• Special Topic on EndometriosisAssociated Pain • Previous Articles    

Therapeutic effect of dienogest in endometriosis-associated pain: from fundamental research to clinical practice

LIANG Yanchun1,2,3, YAN Ying1, MAI Huaxi2, YAO Shuzhong2,3   

  1. 1. Department of Obstetrics and Gynecology, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning 530025, Guangxi, China;
    2. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China;
    3. Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou 510080, Guangdong, China
  • Published:2025-10-17

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Abstract: Pain is the main symptom of patients with endometriosis(EMs). The pathogenesis of endometriosis-associated pain is complex. Dienogest, as one of the key drugs for the treatment of EMs associated pain, plays a crucial role in the long-term management of EMs. This review deeply analyzed the pathogenesis of EMs associated pain, and confirmed that in multiple research evidence, dienogest can reduce EMs lesions, alleviate inflammatory reactions, regulate nerve growth factors, and control central nervous system allergies through various mechanisms of action, thereby achieving the therapeutic effect of controlling the progression of EMs and relieving pain. It provides scientific basis for further in-depth research on the mechanism and clinical application effects of dienogest.

Key words: Endometriosis, Neuropathic pain, Pathogenesis, Inflammatory microenvironment, Dienogest

CLC Number: 

  • R711.71
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