Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (12): 88-93.doi: 10.6040/j.issn.1671-7554.0.2022.0752

Previous Articles    

Changes of antibiotic resistance rates of Morganella morganii in 11 regions of Shandong Province from 2016 to 2021

SUN Yifeng1,17, LI Wei1, SUN Shiying2, GU Anman3, TAN Shengnan4, FU Xunye5, WANG Haizhi6, JI Jianfen7, GUAN Yuwang8, WU Xiangqian9, HE Zhicheng10, WEN Zhaoyang11, YU Shangjia12, LI Shiyi13, LIU Xinghong14, CHEN Ying15, WANG Tingting16, SUN Yundong17   

  1. 1. Department of Clinical Laboratory, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Clinical Laboratory, Qilu Hospital(Qingdao)of Shandong University, Cheeloo College of Medicine, Qingdao 266035, Shandong, China;
    3. Department of Infection Management Office, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    4. Department of Clinical Laboratory, Rushan Peoples Hospital, Rushan 264599, Shandong, China;
    5. Department of Clinical Laboratory, Zibo Integrative Medicine Hospital, Zibo 255020, Shandong, China;
    6. Department of Clinical Laboratory, Weifang No.2 Peoples Hospital, Weifang 261041, Shandong, China;
    7. Department of Clinical Laboratory, Linshu County Peoples Hospital, Linshu 276799, Shandong, China;
    8. Department of Clinical Laboratory, Liangshan County Peoples Hospital, Liangshan 272699, Shandong, China;
    9. Department of Clinical Laboratory, PKU Care Luzhong Hospital, Zibo 255499, Shandong, China;
    10. Department of Orthopedic Surgery, PKU Care Luzhong Hospital, Zibo 255499, Shandong, China;
    11. Department of Clinical Laboratory, The First School Clinical Medicine of Binzhou Medical University, Binzhou 256699, Shandong, China;
    12. Department of Clinical Laboratory, Qixia City Peoples Hospital, Qixia 265399, Shandong, China;
    13. Department of Clinical Laboratory, Rongcheng Hospital of Traditional Chinese Medicine, Rongcheng 264399, Shandong, China;
    14. Department of Clinical Laboratory, The Peoples Hospital of Zhaoyuan City, Zhaoyuan 265499, Shandong, China;
    15. Department of Clinical Laboratory, Peoples Hospital of Rizhao, Rizhao 276827, Shandong, China;
    16. Department of Clinical Laboratory, Ningjin County Peoples Hospital, Ningjin 253499, Shandong, China;
    17. Department of Pathogenic Biology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2022-12-01

PDF (PC)

69

Abstract: Objective To investigate the changing trend of antibiotic resistance of Morganella morganii in Shandong Province from 2016 to 2021, and to explore the drug resistance characteristics, in order to provide data support for rational clinical use. Methods The drug resistance data of 838 clinical isolates of Morganella morganii from 14 hospitals in 11 regions of Shandong Province from 2016 to 2021 were retrospectively analyzed. According to the tissue sources, the isolated specimens were divided into urinary tract(UT)group(n=271), respiratory tract(RT)group(n=161), skin soft tissue(SST)group(n=294)and other groups(n=112). Linear regression was used to analyze the trend of drug resistance, and Pearson χ2 or Fishers exact test were used to analyze the differences among groups. Results From 2016 to 2021, the resistance rate of Morganella morganii to ampicillin/sulbactam showed a linear downward trend(P=0.005), while the resistance rate to cefoperazone/sulbactam showed a linear upward trend(P=0.006). The drug resistance rate of Morganella morganii to levofloxacin in Shandong Province from 2017 to 2020 was higher than that of the national level(P<0.05). The drug resistance rates of Morganella morganii in the UT group to amikacin, gentamicin, tobramycin, aztreonam, ampicillin/sulbactam, piperacillin/tazobactam, compound sulfamethoxazole, ciprofloxacin and levofloxacin were higher than those in RT group(all P<0.05). The resistance rates of Morganella morganii to gentamicin, cefepime, aztreonam, piperacillin/tazobactam, ciprofloxacin and levofloxacin in the UT group were higher than those in the SST group(all P<0.05). Conclusion In Shandong Province, the drug resistance of Morganella morganii to a variety of antibiotics is generally high, and the drug resistance to quinolones is the highest. Medical institutions at all levels should strengthen the rational application of quinolones. The use of cefoperazone/sulbactam, piperacillin/tazobactam, cefepime, and amikacin as first-line agents for the treatment of Morganella morganii infection is recommended.

Key words: Morganella morganii, Antibiotic resistance, Aminoglycosides, Quinolones, Rational drug use, Shandong Province

CLC Number: 

  • R446.5
[1] OHara CM, Brenner FW, Miller JM. Classification, identification, and clinical significance of Proteus, Providencia, and Morganella [J]. Clin Microbiol Rev, 2000,13(4): 534-546.
[2] Pham B, Denslow A, Mikhael M, et al. A case of an extremely low birth weight infant with Morganella morganii bacteremia and peritonitis [J]. AJP Rep, 2021, 11(2): e113-e118.
[3] Paul SP, Newman LM, Mubashar Y, et al. Morganella morganii: a rare cause of early onset neonatal sepsis and meningitis [J]. Br J Hosp Med(Lond), 2020, 81(10): 1-3.
[4] Anagnostakos K, Grzega C, Sahan I, et al. Occurrence of rare pathogens at the site of periprosthetic hip and knee joint infections: a retrospective, single-center study [J]. Antibiotics(Basel), 2021, 10(7): 882. doi:10.3390/antibiotics10070882.
[5] Almater AI, Abusayf MM, Alshahrani S, et al. Paraneoplastic pemphigus associated with rapidly progressing endophthalmitis caused by Morganella morganii: a case report [J]. Eur J Ophthalmol, 2021, 11206721211033465. doi: 10.1177/11206721211033465.
[6] 李春辉, 吴安华. MDR、XDR、PDR多重耐药菌暂行标准定义—国际专家建议[J].中国感染控制杂志, 2014,13(1): 62-64. LI Chunhui, WU Anhua. Interim standard definitions of MDR, XDR and PDR multidrug resistant bacteria: international expert recommendations [J]. Chinese Journal of Infection Control, 2014,13(1): 62-64.
[7] Yang JH, Sheng WH, Hsueh PR. Antimicrobial susceptibility and distribution of extended-spectrum β-lactamases, AmpC β-lactamases and carbapenemases among Proteus, Providencia and Morganella isolated from global hospitalised patients with intra-abdominal and urinary tract infections: results of the Study for Monitoring Antimicrobial Resistance Trends(SMART), 2008-2011 [J]. J Glob Antimicrob Resist, 2020, 22: 398-407. doi: 10.1016/j.jgar.2020.04.011.
[8] 胡付品, 郭燕, 朱德妹, 等. 2017年CHINET中国细菌耐药性监测[J]. 中国感染与化疗杂志, 2018, 18(3): 241-251. HU Fupin, GUO Yan, ZHU Demei, et al. Antimicrobial resistance profile of clinical isolates in hospitals across China: report from the CHINET Surveillance Program, 2017 [J]. Chinese Journal of Infection and Chemotherapy, 2018, 18(3): 241-251.
[9] 胡付品, 郭燕, 朱德妹, 等. 2018年CHINET中国细菌耐药性监测[J]. 中国感染与化疗杂志, 2020, 20(1): 1-10. HU Fupin, GUO Yan, ZHU Demei, et al. CHINET surveillance of bacterial resistance in China: 2018 report [J]. Chinese Journal of Infection and Chemotherapy, 2020, 20(1): 1-10.
[10] 胡付品, 郭燕, 朱德妹, 等. 2019年CHINET三级医院细菌耐药监测[J]. 中国感染与化疗杂志, 2020, 20(3): 233-243. HU Fupin, GUO Yan, ZHU Demei, et al. CHINET surveillance of bacterial resistance across tertiary hospitals in 2019 [J]. Chinese Journal of Infection and Chemotherapy, 2020, 20(3): 233-243.
[11] 胡付品, 郭燕, 朱德妹, 等. 2020年CHINET中国细菌耐药监测[J]. 中国感染与化疗杂志, 2021, 21(4): 377-387. HU Fupin, GUO Yan, ZHU Demei, et al. CHINET surveillance of bacterial resistance: results of 2020 [J]. Chinese Journal of Infection and Chemotherapy, 2021, 21(4): 377-387.
[12] Shi H, Chen X, Yao Y, et al. Morganella morganii: an unusual analysis of 11 cases of pediatric urinary tract infections [J]. J Clin Lab Anal, 2022, 36(5): e24399. doi:10.1002/jcla.24399.
[13] Laupland KB, Paterson DL, Edwards F, et al. Morganella morganii, an emerging cause of bloodstream infections [J]. Microbiol Spectr, 2022, 10(3): e0056922. doi:1 0.1128/spectrum.00569-22.
[14] Amini M, Motie MR, Amel Jamehdar S, et al. Concomitant empyema and peritonitis with Morganella morganii in an immunocompetent patient: a case report [J]. Caspian J Intern Med, 2021, 12(2):232-235.
[15] Zaric RZ, Jankovic S, Zaric M, et al. Antimicrobial treatment of Morganella morganii invasive infections: systematic review [J]. Indian J Med Microbiol, 2021, 39(4): 404-412.
[16] Bandy A. Ringing bells: Morganella morganii fights for recognition [J]. Public Health, 2020, 182: 45-50. doi: 10.1016/j.puhe.2020.01.016.
[17] Learman BS, Brauer AL, Eaton KA, et al. A rare opportunist, Morganella morganii, decreases severity of polymicrobial catheter-associated urinary tract infection [J]. Infect Immun, 2019, 88(1): e00691-19.
[18] 胡丽庆,黄宇雯. 摩根摩根菌的临床分布及耐药性分析[J]. 中国卫生检验杂志, 2017, 27(8): 1182-1184. HU Liqing, HUANG Yuwen. Study on the clinical distribution and drug-resistance of Morganella morganii [J]. China Journal of Health Inspection, 2017, 27(8): 1182-1184.
[19] 夏冰, 郭远瑜. 摩根摩根菌的临床分布及碳青霉烯类药物敏感性分析[J]. 中国卫生检验杂志, 2019, 29(14): 1703-1705. XIA Bing, GUO Yuanyu. Clinical distribution of Morganella morganii and drug sensitivity analysis of carbapenems [J]. China Journal of Health Inspection, 2019, 29(14): 1703-1705.
[20] 王磊, 杨雪静, 陈益民. 摩根摩根菌临床分布及耐药性分析[J]. 中国微生态学杂志, 2016, 28(10):1194-1196. WANG Lei, YANG Xuejing, CHEN Yimin. Clinical distribution and antimicrobial resistance of Morganella morganii [J]. Chinese Journal of Microecology, 2016, 28(10): 1194-1196.
[21] 李金, 胡志东, 汪复, 等. 2005—2014年CHINET变形杆菌属, 沙雷菌属, 枸橼酸杆菌属,摩根菌属及普罗威登菌属细菌耐药性监测[J]. 中国感染与化疗杂志, 2016, 16(3): 284-293. LI Jin, HU Zhidong, WANG Fu, et al. Changing resistance profile of Proteus, Serratia, Citrobacter, Morganella and Providencia isolates in hospitalsacross China: data from CHINET Antimicrobial Resistance Surveillance Program 2005-2014 [J]. Chinese Journal of Infection and Chemotherapy, 2016, 16(3): 284-293.
[22] 王凤霞, 安新业, 李金玲, 等. 2011—2018年滨州市某院大肠埃希菌的分布及耐药性[J].国际流行病学传染病学杂志, 2020, 47(2): 149-153. WANG Fengxia, AN Xinye, LI Jinling, et al. Distribution and drug resistance of Escherichia coli isolated in one hospital of Binzhou during 2011-2018 [J]. International Journal of Epidemiology and Infectious Diseases, 2020, 47(2), 149-153.
[23] 邓慧玲, 张玉凤, 蔡慧君, 等. 儿童嗜麦芽窄食单胞菌临床分离株耐药性多中心研究[J].中国感染与化疗杂志, 2021, 21(4): 456-460. DENG Huiling, ZHANG Yufeng, CAI Huijun, et al. A multicenter study on drug resistance of clinical isolates of Stenotrophomonas maltophilia in children [J]. Chinese Journal of Infection and Chemotherapy, 2021, 21(4): 456-460.
[24] Stultz JS, Bice T, Johnstone K, et al. Importance of reviewing antibiotic courses by 48 hours: risk factors for third-generation cephalosporin resistance among Amp-Charboring organisms in urine and respiratory cultures [J]. Pediatr Infect Dis J, 2021, 40(5): 440-445.
[25] 赵晓东, 吕传柱, 于学忠, 等. 喹诺酮类抗菌药物急诊临床应用指导意见[J]. 中国急救医学, 2020, 40(11): 1047-1056. ZHAO Xiaodong, LV Chuanzhu, YU Xuezhong, et al. Guidelines for the emergency clinical application of quinolones [J]. Chinese Emergency Medicine, 2020, 40(11): 1047-1056.
[1] CAO Aihua, DUAN Chunhong, QIU Bingping, LU Ling, LI Keliang, LIU Xuegong, ZHOU Zhiyuan, SUN Jianhua, JU Xiuli. Epidemiological and clinical characteristics of children infected with SARS-CoV-2 in Shandong Province [J]. Journal of Shandong University (Health Sciences), 2020, 58(6): 34-40.
[2] ZHOU Shengyu, WANG Chunting, ZHANG Wei, WANG Ximing, DONG Liang. Clinical characteristics and treatment effect of 537 cases of novel coronavirus pneumonia in Shandong Province [J]. Journal of Shandong University (Health Sciences), 2020, 58(3): 44-51.
[3] LIU Guanyi, YANG Liyuan, FU Zhentao, XU Aiqiang, GUO Xiaolei. Incidence and mortality of oral cancer in Shandong Province in 2014 [J]. Journal of Shandong University (Health Sciences), 2019, 57(7): 102-107.
[4] HE Dongyang, SUN Jiyao, WANG Meng, WANG Jian, HUANG Guo. Comparison of the characteristics of inpatients’ disease distribution in a tertiary hospital in Shandong Province in 2006 and 2016 [J]. Journal of Shandong University (Health Sciences), 2018, 56(4): 81-86.
[5] ZHAO Qingqing, YIN Geping. Association between genetic polymorphisms of 5 genetic loci of TNF-α promoter and genetic susceptibility to cervical cancer [J]. Journal of Shandong University (Health Sciences), 2018, 56(2): 28-33.
[6] WANG Meijian, HOU Xinguo, LIANG Kai, CHEN Li. Serum lipids and lipoproteins in middle-aged and elderly Chinese in Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 70-75.
[7] YANG Ding,YANG Peng, LI Yubo, SUN Qiang. Changes in prescriptions for upper respiratory tract infections in Z county of Shandong Province:a panel data analysis of 8 village clinics [J]. Journal of Shandong University (Health Sciences), 2017, 55(12): 88-94.
[8] LI Yan, LIU Kun, SUN Xiaojie. Health inequality related to income and influencing factors of the rural elderly in three counties of Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 91-96.
[9] WANG Xing, ZHANG Xiyu, LIN Weiwei, LIAN Ying, ZHANG Qingqing, LI Qilong, LI Shixue. Present situation and existing problems of telemedicine in Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 90-94.
[10] CHEN Si, WANG Muchuan, REN Nannan, XU Wei, WANG Lingling, LUAN Haihui, MA Jun, LIU Yiming. Relationship between polymorphisms of Parkin gene and the risk of Parkinson's disease in Han nationality of Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(4): 71-74.
[11] WANG Hao, ZHANG Na, XUE Fuzhong, WANG Ping, KANG Dianmin, LIU Yanxun. Spatial epidemiological characteristics of HIV infections and AIDS patients in Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 81-86.
[12] ZHANG Min, MU Xiaonan, MA Weiyuan, DANG Ningning, ZHANG Nan. Clinical features and prognostic factors of cutaneous malignant melanoma in Shandong Province: report of 61 cases [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(11): 80-84.
[13] LIU Zhenyan, HU Bin, BI Zhenwang, KOU Zengqiang, FANG Ming, CHEN Baoli, REN Yanyan, BI Zhenqiang. Antibiotic resistance on group A streptococcus among children in 4 cities of Shandong Province in 2013 [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(1): 77-80.
[14] WANG Chuan1, HOU Xinguo1, LIANG Kai1, YAN Fei1, YANG Junpeng1, WANG Lingshu1, TIAN Meng1, LI Chengqiao2, ZHANG Xiuping3, YANG Weifang4, MA Zeqiang5, CHEN Li1. HDL-C and TG/HDL-C ratio to identify insulin resistance in middle-aged and older Hui ethnic population in Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(5): 73-76.
[15] YUAN Yu-qi1, HU Bin2, BI Zhen-wang2, KOU Zeng-qiang2, HOU Pei-bin2, FANG Ming2, LV Hui2, SUN Wen-kui2, LIU Zhen-yan1, BI Zhen-qiang1,2. Identification and characteristics of Vibrio cholerae O139 strains in one patient from Shandong Province of China in 2013 [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(2): 97-100.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd