Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (10): 112-117.doi: 10.6040/j.issn.1671-7554.0.2019.490

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An analysis of the duration and clinical efficacy of pre-transition infantile spasm

JIA Guijuan, LI Baomin, LEI Gefei, SUN Ruopeng, LIU Xinjie   

  1. Department of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the correlation between duration of pre-transition infantile spasm and clinical efficacy. Methods The clinical and electroencephalogram data, follow-up results and prognosis of 63 infants with pre-transition spasm were retrospectively analyzed. Results There were 40 male(63.5%)and 23 female(36.5%)infants. The onset was ≤1 year in 50 patients(79.36%), and >1 year in 13 patients(20.64%). Duration of the transition was 14 days to 23 months, average 8.06 months, median 6 months. The interval of seizure transition was ≤3 months in 10 patients(15.87%), and >3 months in 53 patients(84.13%). Latent causes were found in 28 cases(44.44%)and no obvious causes were found in 35 cases(55.56%). VEEG confirmed that 29 cases(46.03%)had the first tonic episode as the transition point, and 34 cases(53.97%)had transition point mixed with other seizure types. Clinical spasm remission was related to gender and transition interval, and the differences were statistically significant(P<0.05), but not related to the age of onset and the presence of latent etiology(P>0.05). Conclusion The remission rate of spasm is worse in males than in females and those with shorter duration of spasm before transition have better prognosis.

Key words: Epilepsy, Infantile spasm, Hypsarrhythmia, Seizure, Transition

CLC Number: 

  • R722
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