Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (7): 55-60.doi: 10.6040/j.issn.1671-7554.0.2019.475

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Anti-inflammation effect of baicalin on rat models of nonalcoholic steatohepatitis

AI Zhenglin1, HONG Shan1, HU Julong1, LI Ping1, ZHOU Yuling1, LIANG Xiuxia1, YAO Shukun2   

  1. 1. Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;
    2. Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China
  • Published:2022-09-27

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Abstract: Objective To investigate the efficacy of baicalin in the treatment of non-alcoholic steatohepatitis(NASH)in rat models and the anti-inflammatory effect. Methods After NASH rat models were induced, they were intragastrically given different doses of baicalin 15, 30, 60 mg/(kg·d). The body weight and liver weight were measured. The histopathology changes in hepatic steatosis were observed with hematoxylin-eosin(HE)staining. The serum alanine amiotransferase(ALT)and aspartate aminotransferase(AST)levels were assessed. The changes of hepatic reduced glutathione hormone(GSH), superoxide dismutase(SOD)and hepatic malondialdehyde(MDA)were detected with spectrophotometry. The levels of tumor necrosis factor α(TNFα), interleukin 6(IL-6)and interleukin 1β(IL-1β)in liver tissues were measured with enzyme linked immunosorbent assay(ELASA). Results After baicalin treatment, the body weight and liver weight of NASH rats were significantly reduced(F=1 609.79, P<0.001; F=155.17, P<0.001) 山 东 大 学 学 报 (医 学 版)57卷7期 -艾正琳,等.黄芩苷治疗非酒精性脂肪性肝炎大鼠抗炎的疗效 \=-in a dose-dependent manner. The steatosis of hepatic cells gradually decreased, and the infiltration of inflammatory cells was relieved. The serum ALT and AST reduced(F=177.16, P<0.001; F=2 998.11, P<0.001), the activity of GSH and SOD increased(F=398.47, P<0.001; F=256.07, P<0.001); the MDA;TNFα, IL-1β and IL-6 levels decreased(F=237.98, P<0.001;F=399.15, P<0.001; F=314.76, P<0.001; F=108.38, P<0.001), in a dose-dependent manner. Conclusion Baicalin can alleviate the degree of steatosis and inflammation in NASH rats. By increasing the activity of GSH and SOD enzymes, and reducing the levels of TNFα, IL-1β and IL-6, it exerts anti-inflammatory effects and alleviates liver inflammation.

Key words: Baicalin, Anti-inflammation, Nonalcoholic steatohepatitis, Tumor necrosis factor α, Interleukin

CLC Number: 

  • R575.1
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