Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (5): 93-97.doi: 10.6040/j.issn.1671-7554.0.2019.1443

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Three cases of amyloidosis with diarrhea as the first symptom and literature review

WANG Baihui1, SONG Yanjun2, ZHANG Shuaiqing1, ZUO Xiuli3, WANG Qing1, ZHANG Aijun1, LI Ruyuan1   

  1. 1.Department of Gastroenterology, Qilu Hospital of Shandong University(Qingdao), Qingdao 266000, Shandong, China;
    2.Department of Hematology, Qilu Hospital of Shandong University(Qingdao), Qingdao 266000, Shandong, China;
    3.Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To summarize the clinical manifestations, primary diseases and diagnosis of digestive tract amyloidosis. Methods The clinical data of 3 cases of digestive tract amyloidosis treated in department of gastroenterology,Qilu Hospital of Shandong University(Qingdao)were analyzed and relevant literature was reviewed. Results This disease had no specific clinical manifestations, which included gastrointestinal bleeding, abdominal pain, diarrhea, poor appetite and abdominal distension. Colonoscopy indicated mucosal hyperemia and irregular ulcers. Conclusion Digestive tract amyloidosis is a rare disease with complex nonspecific clinical manifestations and high misdiagnosis rate. Chronic diarrhea secondary to amyloidosis is often atypical at the initial stage. Multisystem functional impairment occurs as the disease progresses rapidly and results in poor prognosis. Therefore, amyloidosis should be differentiated from chronic diarrhea in clinical practice. Timely identification of multisystem damage and pathological biopsy are useful in the diagnosis of amyloidosis and can improve patients survival rate.

Key words: Amyloidosis, Digestive tract, Diarrhea, Systemic lupus erythematosus, Multiple myeloma

CLC Number: 

  • R442.2
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