Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (12): 13-18.doi: 10.6040/j.issn.1671-7554.0.2018.183

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Risk factors of portal vein thrombosis in patients with liver cirrhosis

DING Yanfei, YANG Zhuoxin, ZHENG Wenwen, YUAN Wenjie, GAO Yanjing   

  1. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To investigate the risk factors of portal vein thrombosis(PVT)in cirrhotic patients. Methods The clinical data of 1 670 hospitalized cirrhotic patients were retrospectively analyzed, of whom 217 with PVT were classified into the PVT group, while 250 without PVT were randomized into the non-PVT group. The general information, laboratory results, clinical manifestations, complications, surgery and drug administration history of the two groups were recorded. The risk factors of PTV were analyzed with univariate analysis and multivariate Logistic regression analysis. Results Of the 1 670 cirrhotic patients, 13% developed PVT, whose liver function was classified as Child-Pugh B and C. Univariate analysis showed significant differences in d-dimer, hemoglobin(Hb), total bilirubin(TBiL), severe esophageal varices, previous splenectomy, hemostatic drugs and propranolol between the two groups. Multivariate Logistic regression analysis showed that severe esophageal varices(OR=6.918, P=0.018), previous splenectomy(OR=4.281, P=0.007)and increase of d-dimer(OR=5.007, P<0.001)were independent risk factors of PVT. Conclusion Hemostatic drugs, propranolol, increase of d-dimer, severe esophageal varices, previous splenectomy may be associated with the formation of PVT in cirrhotic patients. Severe esophageal varices, previous splenectomy and increase of d-dimer are independent risk factors of PVT.

Key words: Liver cirrhosis, Venous thrombosis, Portal vein, Risk factors

CLC Number: 

  • R575.2
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