Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (12): 7-12.doi: 10.6040/j.issn.1671-7554.0.2018.463

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Expression and prognostic significance of apoptosis antagonizing transcription factor in hepatocellular carcinoma

SHAO Qianqian1, WANG Jingpu2, WANG Qingjie1   

  1. 1. Institute of Basic Medical Sciences, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Ultrasound, Longkou Traditional Chinese Medicine Hospital, Longkou 265701, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To analyze the expression and prognostic significance of apoptosis antagonizing transcription factor(AATF)in liver hepatocellular carcinoma(LIHC). Methods The mRNA and protein expressions and location of AATF in LIHC tissues and control tissues were detected with GEPIA and the Human Protein Atlas. The genomic alterations of AATF in LIHC tissues and the protein network diagram associated with AATF protein were assessed with cBioPortal. The effects of AATF on the 5-year survival and overall survival of liver cancer patients were determined with Kaplan-Meier Plotter. The prognostic significance of AATF in LIHC patients was analyzed with Tumor Immune Estimation Resource. Results Compared with the control tissues, the LIHC tissues showed significantly up-regulated mRNA(P<0.05)and protein expressions of AATF. AATF protein was located in the membrane and cytoplasm of LIHC cells. The genomic alterations of AATF had a low incidence in LIHC. The proteins that interacted with AATF included ATM, CHEK2, and so on, which were mainly involved in the regulation of cell cycle, apoptosis, and transcriptional regula- 山 东 大 学 学 报 (医 学 版)56卷12期 -邵倩倩,等. 抗凋亡转录因子在肝细胞肝癌中的表达及预后作用 \=-tion. The mRNA expression of AATF was negatively correlated with the prognosis of LIHC(log-rank P=0.003). Conclusion AATF is highly expressed in LIHC tissues and associated with poor prognosis.

Key words: Apoptosis antagonizing transcription factor, Liver hepatocellular carcinoma, Prognosis, Data analysis

CLC Number: 

  • R735.7
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