Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (2): 11-15.doi: 10.6040/j.issn.1671-7554.0.2018.1382

Previous Articles    

Effects of climacteric and menopausal hormone therapy on immune system

SHI Yuhua1, ZHENG Qingmei2   

  1. 1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology 〓山〓东〓大〓学〓学〓报〓(医〓学〓版)57卷2期〓-石玉华, 等.更年期及绝经激素治疗对免疫系统的影响〓\=-and Reproductive Genetics;
    The Key Laboratory of Reproductive Endocrinology(Shandong University), Ministry of Education;
    Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250001, Shandong, China;
    2. Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China
  • Published:2022-09-27

PDF (PC)

18

Abstract: Ovarian dysfunction is a prominent manifestation of female aging. Women will experience menstrual changes until menopause, accompanied by a variety of menopausal-related symptoms. Menopause not only has a persistent adverse effect on cardiovascular, skeletal and cognitive functions, but also leads to various changes in the immune system. Studies have shown that estrogen can regulate humoral and cellular immunity, and the imbalance of estrogen content and function can lead to immune dysfunction. Menopausal hormone therapy can not only improve menopausal-related symptoms, but also improve ovarian hormone deficiency-related immune aging, enhance the immune function of normal aging women, and improve the quality of life of menopausal women.

Key words: Climacteric, Menopause, Menopausal hormone therapy, Immune system, Effect

CLC Number: 

  • R711.75
[1] 谢梅青, 陈蓉, 任慕兰. 中国绝经管理与绝经激素治疗指南(2018)[J]. 协和医学杂志, 2018, 9(6): 512-525.
[2] Harlow SD, Gass M, Hall JE, et al. Executive summary of the Stages of Reproductive Aging Workshop+10: addressing the unfinished agenda of staging reproductive aging[J]. J Clin Endocrinol Metab, 2012, 97(4): 1159-1168.
[3] 于爱莲, 王月丹. 病原生物学与免疫学[M]. 北京:北京大学医学出版社, 2015.
[4] Bodey B, Bodey B Jr, Siegel SE, et al. Molecular biological ontogenesis of the thymic reticulo-epithelial cell network during the organization of the cellular microenvironment[J]. In Vivo, 1999, 13(3): 267-294.
[5] Grimaldi CM, Hill L, Xu XN, et al. Hormonal modulation of B cell development and repertoire selection[J]. Mol Immunol, 2005, 42(7): 811-820.
[6] Medina KL, Strasser A, Kincade PW. Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors[J]. Blood, 2000, 95(6): 2059-2067.
[7] Franceschi C, Monti D, Barbieri D, et al. Immunosenescence in humans: deterioration or remodelling?[J]. Int Rev Immunol, 1995, 12(1): 57-74.
[8] Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants[J]. Science, 2002, 295(5562): 2097-2100.
[9] Rubnitz JE, Inaba H, Ribeiro RC, et al. NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia[J]. J Clin Oncol, 2010, 28(6): 955-959.
[10] Borrego F, Alonso MC, Galiani MD, et al. NK phenotypic markers and IL2 response in NK cells from elderly people[J]. Exp Gerontol, 1999, 34(2): 253-265.
[11] Kutza J, Murasko DM. Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples[J]. Mech Ageing Dev, 1996, 90(3): 209-222.
[12] 崔红旺, 孟志斌, 王挺锐, 等. 雌激素缺乏上调TNF-α促发卵巢切除大鼠骨细胞程序性坏死[J]. 中国骨质疏松杂志, 2017, 23(11): 1431-1437. CUI Hongwang, MENG Zhibin, WANG Tingrui, et al. Estrogen deficiency promotes osteocyte necroptosis in OVX rats by up-regulating TNF-α[J]. Chinese Journal of Osteoporosis, 2017, 23(11): 1431-1437.
[13] Cutolo M, Montagna P, Brizzolara R, et al. Sex hormones modulate the effects of Leflunomide on cytokine production by cultures of differentiated monocyte/macrophages and synovial macrophages from rheumatoid arthritis patients[J]. J Autoimmun, 2009, 32(3/4): 254-260.
[14] Lio D, Balistreri CR, Candore G, et al. In vitro treatment with interleukin-2 normalizes type-1 cytokine production by lymphocytes from elderly[J]. Immunopharmacol Immunotoxicol, 2000, 22(2): 195-203.
[15] Kim OY, Chae JS, Paik JK, et al. Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women[J]. Age(Dordr), 2012, 34(2): 415-425.
[16] Berg G, Ekerfelt C, Hammar M, et al. Cytokine changes in postmenopausal women treated with estrogens: a placebo-controlled study[J]. Am J Reprod Immunol, 2002, 48(2): 63-69.
[17] Verma P, Verma R, Nair RR, et al. Altered crosstalk of estradiol and progesterone with Myeloid derived suppressor cells and Th1/Th2 cytokines in early miscarriage is associated with early breakdown of maternal-fetal tolerance[J]. Am J Reprod Immunol, 2018: e13081. doi: 10.1111/aji.13081.
[18] Salem ML. Estrogen, a double-edged sword: modulation of TH1- and TH2-mediated inflammations by differential regulation of TH1/TH2 cytokine production[J]. Curr Drug Targets Inflamm Allergy, 2004, 3(1): 97-104.
[19] Kamada M, Irahara M, Maegawa M, et al. Transient increase in the levels of T-helper 1 cytokines in postmenopausal women and the effects of hormone replacement therapy[J]. Gynecol Obstet Invest, 2001, 52(2): 82-88.
[20] 卢寨娥, 蒋竞. 雌激素治疗对绝经妇女Th1/Th2平衡的影响[J]. 浙江医学, 2014, 36(2): 118-119,123. LU Zhaie, JIANG Jing. Effects of estrogen therapy on the Th1/Th2 balance in postmenopausal women[J]. Zhejiang Medical Journal, 2014, 36(2): 118-119,123.
[21] Kumru S, Godekmerdan A, Yilmaz B. Immune effects of surgical menopause and estrogen replacement therapy in peri-menopausal women[J]. J Reprod Immunol, 2004, 63(1): 31-38.
[22] Porter VR, Greendale GA, Schocken M, et al. Immune effects of hormone replacement therapy in post-menopausal women[J]. Exp Gerontol, 2001, 36(2): 311-326.
[23] Tani AN, Yasui T, Matsui S, et al. Different circulating levels of monocyte chemoattractant protein-1 and interleukin-8 during the menopausal transition[J]. Cytokine, 2013, 62(1): 86-90.
[24] Koh KK, Son JW, Ahn JY, et al. Effect of hormone replacement therapy on nitric oxide bioactivity and monocyte chemoattractant protein-1 levels[J]. Int J Cardiol, 2001, 81(1): 43-50.
[25] Miyatani Y, Yasui T, Uemura H, et al. Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women[J]. Menopause, 2008, 15(3): 536-541.
[26] Ghosh M, Rodriguez-Garcia M, Wira CR. The immune system in menopause: pros and cons of hormone therapy[J]. J Steroid Biochem Mol Biol, 2014, 142:171-175. doi: 10.1016/j.jsbmb.2013.09.003.
[27] de Villiers TJ, Hall JE, Pinkerton JV, et al. Revised global consensus statement on menopausal hormone therapy[J]. Climacteric, 2016, 19(4): 313-315.
[28] Baber RJ, Panay N, Fenton A, et al. 2016 IMS Recommendations on womens midlife health and menopause hormone therapy[J]. Climacteric, 2016, 19(2): 109-150.
[1] MA Xiang, ZHAO Feiyan. Status and progress of oocyte cryopreservation [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 19-23.
[2] FU Jia, WANG Lulu, HU Shuai, CHEN Zheping, LIU Dongyi, LI Qingsong, LU Guodong, ZHANG He, ZHAO Xin, FENG Chang. Effects of different approaches of quadrates lumborum block on postoperative recovery of patients undergoing radical gastrectomy [J]. Journal of Shandong University (Health Sciences), 2022, 60(8): 50-57.
[3] LI Hongwen, ZHOU Zifu, WANG Song, HUO Ran. Cost-effectiveness analysis of staged excision compared with one-stage excision of facial pigmented nevus in children [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 123-128.
[4] CAO Danfeng, LIU Zonghua, WANG Junzhi, ZHANG Guoxiang. The independent and cumulative associations of childhood household dysfunction with depressive symptoms during pregnancy [J]. Journal of Shandong University (Health Sciences), 2022, 60(6): 97-101.
[5] SUN Jiye, WANG Ziou, SUN Xiaowei, LI Hongtao. Effects of traditional Chinese medicine fumigation combined with extracorporeal shock wave therapy on 72 cases of femoroacetabular impingement syndrome and serum inflammatory factor [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 76-81.
[6] DONG Xue, ZHAO Xia, CHENG Zijie, HAN Yi. Pharmacoeconomic evaluation of levosimendan and milrinone in the treatment of 711 patients with severe heart failure complicated with renal injury [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 91-98.
[7] LI Qing, LIN Xueyan, LIU Tianhang, LI Xiaowen, FAN Mingzhe, ZHAO Ruirui, TIAN Yongjie. Medium- and long-term efficacy of transvaginal mesh pelvic floor reconstruction [J]. Journal of Shandong University (Health Sciences), 2022, 60(3): 71-75.
[8] HAO Qiang, GAO Qi, ZHAO Ran, WANG Haitao, LIU Zhidong, JIANG Baofa. Effects of ambient temperature and relative humidity on rotavirus diarrhea among children under 5 years old in Shenzhen City during 2014-2016 [J]. Journal of Shandong University (Health Sciences), 2022, 60(2): 89-95.
[9] CHEN Wei, GUO Qingqing, XU Jin, FANG Yuan, SUN Mei, SHENG Yan. A comparative analysis of the effects of natural cycle combined with luteal ovarian stimulation and dual ovarian stimulation [J]. Journal of Shandong University (Health Sciences), 2021, 59(8): 61-66.
[10] Yuelong SHU,Simin WEN. Research progress on factors influencing the protective effects of influenza vaccines [J]. Journal of Shandong University (Health Sciences), 2021, 59(5): 1-7.
[11] DU Shuang, HAN Dexin, LIN Shaoqian, BAI Shuoxin, ZHAO Xiaodong, WANG Zhaojun, WANG Zhiping. Effect of ambient temperature during pregnancy on the risk of preterm birth [J]. Journal of Shandong University (Health Sciences), 2021, 59(12): 134-142.
[12] LIU Xinyu, WANG Quan, JU Haojie, SUN Xiaojie. Mediating effect of cognition on the relationship between social capital and functional health of elderly people [J]. Journal of Shandong University (Health Sciences), 2021, 59(11): 100-107.
[13] CHEN Qingyi, ZHANG Xuan, WANG Juan, SUN Jiwei, CAO Danfeng, CAO fenglin. Risk factors and cumulative effects of suicidal ideation in pregnant women [J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 91-94.
[14] ZHANG Xiqin, ZHU Shouhui, LIU Ning, WANG Yu, CHEN Jiazhen, HU Xudong. Clinical observation of PEG-rhG-CSF in preventing neutropenia in 80 patients with small cell lung cancer treated with concurrent chemoradiotherapy [J]. Journal of Shandong University (Health Sciences), 2020, 58(12): 43-46.
[15] AN Yan, WANG Lyu, CHEN Cancan, FAN Xiuzhen. Psychological capital and research motivation in 206 nursing postgraduates [J]. Journal of Shandong University (Health Sciences), 2020, 58(12): 102-108.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd