Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (10): 86-92.doi: 10.6040/j.issn.1671-7554.0.2017.925

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Effects of mucin1-C on the biological behaviors of esophageal squamous cell carcinoma cells

GONGSUN Xin, XIN Zhongwei, SHI Mo, QIN Qiming, JIANG Bin, SONG Xuemin, LIU Xiangyan   

  1. Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2017-09-26 Published:2022-09-27

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Abstract: Objective To explore the expression of mucin1-C(MUC1-C)in esophageal squamous cell carcinoma(ESCC)and its role in the malignant biological behaviors of ESCC cells. Methods The expressions of MUC1-C in the ESCC tissues and normal tissues were detected with Western blotting. After MUC1-C entrance into the nucleus was inhibited with Go-201, the activity, growth and proliferation of ESCC cells were assessed with colony-forming assay and CCK-8 test; the cell migration and invasion abilities were measured with wound healing and Transwell assay, respectively; the apoptosis rate was determined with flow cytometry. Results The expression of MUC1-C in ESCC tissues was higher than that in normal tissues. The activity, growth, proliferation, migration and invasion of ESCC cells decreased while the apoptosis rate increased after MUC1-C entrance into the nucleus was inhibited with Go-201. Conclusion MUC1-C can promote the growth, proliferation, migration and invasion while inhibit the apoptosis of ESCC cells.

Key words: Esophageal squamous cell carcinoma, Mucin1-c, Migration, Apoptosis

CLC Number: 

  • R574
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