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山东大学学报 (医学版) ›› 2018, Vol. 56 ›› Issue (10): 93-102.doi: 10.6040/j.issn.1671-7554.0.2017.1017

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豆制品摄入量与胃癌发病风险关系的Meta分析

倪迎春1,杨孝荣1,杜金阁2,吕明1,3   

  1. 1. 山东大学公共卫生学院流行病学系, 山东 济南 250012;2. 山东大学齐鲁医院感染管理处, 山东 济南 250012;3. 山东大学齐鲁医院科研处临床流行病学研究室, 山东 济南250012
  • 收稿日期:2017-10-23 出版日期:2018-10-10 发布日期:2022-09-27
  • 通讯作者: 吕明. E-mail:lvming@sdu.edu.cn

Consumption of soybean products and gastric cancer risk: a systematic review and meta-analysis

NI Yingchun1, YANG Xiaorong1, DU Jinge2, LÜ Ming1,3   

  1. 1. Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Infection Control Unit, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2017-10-23 Online:2018-10-10 Published:2022-09-27

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摘要： 目的 通过Meta分析探讨豆制品摄入量与胃癌发病风险的关系。 方法 两名研究者分别检索PubMed、Web of Science和Embase数据库、中国知网、万方数据库发表的相关文献,用合并OR值和95%CI评价豆制品摄入量与胃癌发病的关系。根据设计类型、研究对象性别和地理区域进行亚组分析。 结果 共纳入53项研究,包括18项队列研究(890 145位参与者中共有5 153例病例)和35项病例对照研究(共有10 692位病例和25 324例对照)。最终共计50项研究(剔除3项质量评分较低的研究)纳入到本次Meta分析中。结果显示:大豆、豆腐和豆浆的高摄入量与胃癌发病风险的降低有关(大豆, OR=0.75,95% CI: 0.66~0.85;豆腐,OR=0.77,95% CI:0.68~0.88;豆浆,OR=0.78,95% CI:0.65~0.94)。亚组分析结果表明,在亚洲人群中较高的大豆和豆腐摄入量与胃癌发病风险呈负相关(大豆,OR=0.80,95% CI: 0.74~0.86;豆腐,OR=0.77,95% CI:0.68~0.88)。 结论 豆制品摄入量增加能降低胃癌的发病风险。

关键词: 豆制品摄入量, 胃癌, 风险, Meta分析

Abstract: Objective To investigate the association between consumption of soybean products and risk of gastric cancer(GC). Methods Relevant literature was searched in PubMed, Web of Science, Embase, CNKI and Wanfang Database from the inception to March 2017. The association between soybean product consumption and GC risk was analyzed with pooled odds ratio(OR)and 95% confidence interval(CI). Subgroup analyses were further performed according to different types of design, genders and geographic regions. Results A total of 53 studies were obtained, including 18 cohort studies with 5 153 cases and 890 145 participants, and 35 case-control studies with 10 692 cases and 25 324 controls. Finally 3 studies with low quality were excluded and 50 studies were included in the systematic review and meta-analysis. The results indicated that higher soybean, tofu and soybean milk consumptions were associated with a decreased risk of GC(soybean, OR=0.75, 95%CI: 0.66-0.85; tofu, OR=0.77, 95%CI: 0.68-0.88; soybean milk, OR=0.78, 95%CI: 0.65-0.94). Subgroup analyses suggested that higher soybean and tofu consumptions were negatively associated with GC risk(soybean, OR=0.80, 95%CI: 0.74-0.86; tofu, OR=0.77, 95%CI: 0.68-0.88)among Asians. Conclusion High intake of soybean, tofu and soybean milk can reduce the risk of GC.

Key words: Soybean products, Gastric cancer, Risk, Meta-analysis

中图分类号: 

  • R181.3
[1] Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012[J]. Int J Cancer, 2015, 136(5): E359-386.
[2] Van Cutsem E, Sagaert X, Topal B, et al. Gastric cancer[J]. Lancet, 2016, 388(10060): 2654-2664.
[3] de Martel C, Forman D, Plummer M. Gastric cancer: epidemiology and risk factors[J]. Gastroenterol Clin North Am, 2013, 42(2): 219-240.
[4] Zhou Y, Zhuang W, Hu W, et al. Consumption of large amounts of allium vegetables reduces risk for gastric cancer in a meta-analysis[J]. Gastroenterology, 2011, 141(1): 80-89.
[5] Fang X, Wei J, He X, et al. Landscape of dietary factors associated with risk of gastric cancer: a systematic review and dose-response meta-analysis of prospective cohort studies[J]. Eur J Cancer, 2015, 51(18): 2820-2832.
[6] Wang T, Cai H, Sasazuki S, et al. Fruit and vegetable consumption, helicobacter pylori antibodies, and gastric cancer risk: a pooled analysis of prospective studies in China, Japan, and Korea[J]. Int J Cancer, 2017, 140(3): 591-599.
[7] Tse G, Eslick GD. Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis[J]. Eur J Nutr, 2016, 55(1): 63-73.
[8] Lu D, Pan C, Ye C, et al. Meta-analysis of soy consumption and gastrointestinal cancer risk[J]. Sci Rep, 2017, 7(1): 4048. doi: 10.1038/s41598-017-03692-y.
[9] Stang A. Critical evaluation of the newcastle-ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J]. Eur J Epidemiol, 2010, 25(9): 603-605.
[10] Hirayama T. Relationship of soybean paste soup intake to gastric cancer risk[J]. Nutr Cancer, 1982, 3(4): 223-233.
[11] Risch HA, Jain M, Choi NW, et al. Dietary factors and the incidence of cancer of the stomach[J]. Am J Epidemiol, 1985, 122(6): 947-959.
[12] Hu JF, Zhang SF, Jia EM, et al. Diet and cancer of the stomach: a case-control study in China[J]. Int J Cancer, 1988, 41(3): 331-335.
[13] You WC, Blot WJ, Chang YS, et al. Diet and high risk of stomach cancer in Shandong, China[J]. Cancer Res, 1988, 48(12): 3518-3523.
[14] Li JY, Ershow AG, Chen ZJ, et al. A case-control study of cancer of the esophagus and gastric cardia in Linxian[J]. Int J Cancer, 1989, 43(5): 755-761.
[15] Nomura A, Grove JS, Stemmermann GN, et al. A prospective study of stomach cancer and its relation to diet, cigarettes, and alcohol consumption[J]. Cancer Res, 1990, 50(3): 627-631.
[16] Gonzalez CA, Sanz JM, Marcos G, et al. Dietary factors and stomach cancer in Spain: a multi-centre case-control study[J]. Int J Cancer, 1991, 49(4): 513-519.
[17] Hoshiyama Y, Sasaba T. A case-control study of stomach cancer and its relation to diet, cigarettes, and alcohol consumption in saitama prefecture, Japan[J]. Cancer Causes Control, 1992, 3(5): 441-448.
[18] Palli D, Bianchi S, Decarli A, et al. A case-control study of sancers of the gastric cardia in Italy[J]. Br J Cancer, 1992, 65(2): 263-266.
[19] Lee JK, Park BJ, Yoo KY, et al. Dietary factors and stomach cancer - a case-control study in Korea[J]. Int J Epidemiol, 1995, 24(1): 33-41.
[20] Zhang ZF, Kurtz RC, Yu GP, et al. Adenocarcinomas of the esophagus and gastric cardia: the role of diet[J]. Nutr Cancer, 1997, 27(3): 298-309.
[21] Botterweck AAM, van den Brandt PA, Goldbohm RA. A prospective cohort study on vegetable and fruit consumption and stomach cancer risk in the Netherlands[J]. Am J Epidemiol, 1998, 148(9): 842-853.
[22] Ji BT, Chow WH, Yang G, et al. Dietary habits and stomach cancer in Shanghai, China[J]. Int J Cancer, 1998, 76(5): 659-664.
[23] Ward MH, Lopez-Carrillo L. Dietary factors and the risk of gastric cancer in Mexico City[J]. Am J Epidemiol, 1999, 149(10): 925-932.
[24] 孙喜文, 戴旭东, 林英姬, 等. 饮食因素与胃癌关系的研究[J]. 实用肿瘤学杂志, 1999, 13(1): 16-19.
[25] Mathew A, Gangadharan P, Varghese C, et al. Diet and stomach cancer: a case-control study in South India[J]. Eur J Cancer Prev, 2000, 9(2): 89-97.
[26] Takezaki T, Gao CM, Wu JZ, et al. Dietary protective and risk factors for esophageal and stomach cancers in a low-epidemic area for stomach cancer in Jiangsu Province, China: comparison with those in a high-epidemic area[J]. Jpn J Cancer Res, 2001, 92(11): 1157-1165.
[27] Kim HJ, Chang WK, Kim MK, et al. Dietary factors and gastric cancer in Korea: a case-control study[J]. Int J Cancer, 2002, 97(4): 531-535.
[28] Nishimoto IN, Hamada GS, Kowalski LP, et al. Risk factors for stomach cancer in Brazil(I): a case-control study among non-Japanese Brazilians in Sao Paulo[J]. Jpn J Clin Oncol, 2002, 32(8): 277-283.
[29] 石美森, 孙喜文, 戴旭东. 哈尔滨市居民胃癌危险因素的病例对照研究[J]. 肿瘤防治研究, 2002, 29(6): 496-497. SHI Meisen, SUN Xiwen, DAI Xudong. A case-control study on risk factors and gastric cancer in Harbin[J]. Cancer Res Prev Tre, 2002, 29(6): 496-497.
[30] Xibin S, Moller H, Evans HS, et al. Residential environment, diet and risk of stomach cancer: a case-control study in Linzhou, China[J]. Asian Pac J Cancer Prev, 2002, 3(2): 167-172.
[31] Lee SA, Kang D, Shim KN, et al. Effect of diet and helicobacter pylori infection to the risk of early gastric cancer[J]. J Epidemiol, 2003, 13(3): 162-168.
[32] 鲍萍萍, 高立峰, 刘大可, 等. 上海市区胃癌危险因素探讨[J]. 肿瘤, 2003, 23(6): 458-463. BAO Pingping, GAO Lifeng, LIU Dake, et al. A case-control study on risk factors for stomach cancer in urban Shanghai[J]. Tumor, 2003, 23(6): 458-463.
[33] 费素娟, 萧树东. 上海市区饮食与胃癌发病的病例对照研究[J]. 胃肠病学, 2003, 8(3): 143-147. FEI Sujuan, XIAO Shudong. Diet and gastric cancer: a case-control study in Shanghai urban districts[J]. Chinese Journal of Gastroenterology, 2003, 8(3): 143-147.
[34] De Stefani E, Correa P, Boffetta P, et al. Dietary patterns and risk of gastric cancer: a case-control study in Uruguay[J]. Gastric Cancer, 2004, 7(4): 211-220.
[35] Nan HM, Park JW, Song YJ, et al. Kimchi and soybean pastes are risk factors of gastric cancer[J]. World J Gastroenterol, 2005, 11(21): 3175-3181.
[36] Freedman ND, Subar AF, Hollenbeck AR, et al. Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study[J]. Cancer Causes Control, 2008, 19(5): 459-467.
[37] Kwang-Pil K, Park SK, Gwack J, et al. Protective effect of soy products against gastric cancer[J]. Cancer Research, 2008, 68: 3086.
[38] Navarro Silvera SA, Mayne ST, Risch H, et al. Food group intake and risk of subtypes of esophageal and gastric cancer[J]. Int J Cancer, 2008, 123(4): 852-860.
[39] Aune D, De Stefani E, Ronco A, et al. Legume intake and the risk of cancer: a multisite case-control study in Uruguay[J]. Cancer Cause Control, 2009, 20(9): 1605-1615.
[40] Pourfarzi F, Whelan A, Kaldor J, et al. The role of diet and other environmental factors in the causation of gastric cancer in Iran-a population based study[J]. Int J Cancer, 2009, 125(8): 1953-1960.
[41] Epplein M, Shu XO, Xiang YB, et al. Fruit and vegetable consumption and risk of distal gastric cancer in the Shanghai womens and mens health studies[J]. Am J Epidemiol, 2010, 172(4): 397-406.
[42] Gao Y, Hu N, Han XY, et al. Risk factors for esophageal and gastric cancers in Shanxi Province, China: A case-control study[J]. Cancer Epidemiol, 2011, 35(6): 91-99.
[43] Steevens J, Schouten LJ, Goldbohm RA, et al. Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study[J]. Int J Cancer, 2011, 129(11): 2681-2693.
[44] Hara A, Sasazuki S, Inoue M, et al. Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan[J]. Am J Clin Nutr, 2012, 95(1): 147-154.
[45] Ko KP, Park SK, Yang JJ, et al. Intake of soy products and other foods and gastric cancer risk: a prospective study[J]. J Epidemiol, 2013, 23(5): 337-343.
[46] Kweon SS, Shu XO, Xiang Y, et al. Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population[J]. J Nutr, 2013, 143(11): 1736-1742.
[47] Shin MH, Hwang SM, Bae JM, et al. Soy and salty food intake and risk of stomach cancer in Seoul Male Cohort[J]. Cancer Research, 2013, 73(8): 4807.
[48] Wada K, Tsuji M, Tamura T, et al. Soy isoflavone intake and stomach cancer risk in Japan: From the Takayama study[J]. Int J Cancer, 2015, 137(4): 885-892.
[49] Yang S, Park Y, Lee J, et al. Effects of soy product intake and interleukin genetic polymorphisms on early gastric cancer risk in Korea: a case-control study[J]. Cancer Res Treat, 2017, 49(4): 1044-1056.
[50] Wu AH, Yang D, Pike MC. A meta-analysis of soyfoods and risk of stomach cancer: the problem of potential confounders[J]. Cancer Epidem Biomar, 2000, 9(10): 1051-1058.
[51] Grosso G, Godos J, Lamuela-Raventos R, et al. A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations[J]. Mol Nutr Food Res, 2017, 61(4). doi: 10.1002/mnfr.201600930.
[52] Akiyama T, Ishida J, Nakagawa S, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases[J]. J Biol Chem, 1987, 262(12): 5592-5595.
[53] Bae EA, Han MJ, Kim DH. In vitro anti-helicobacter pylori activity of irisolidone isolated from the flowers and rhizomes of Pueraria thunbergiana[J]. Planta Med, 2001, 67(2): 161-163.
[54] Verdrengh M, Collins LV, Bergin P, et al. Phytoestrogen genistein as an anti-staphylococcal agent[J]. Microbes Infect, 2004, 6(1): 86-92.
[55] Cui HB, Na XL, Song DF, et al. Blocking effects of genistein on cell proliferation and possible mechanism in human gastric carcinoma[J]. World J Gastroenterol, 2005, 11(1): 69-72.
[56] Liu YL, Zhang GQ, Yang Y, et al. Genistein induces G2/M arrest in gastric cancer cells by increasing the tumor suppressor PTEN expression[J]. Nutr Cancer, 2013, 65(7): 1034-1041.
[57] Tatsuta M, Iishi H, Baba M, et al. Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats[J]. Int J Cancer, 1999, 80(3): 396-399.
[58] Watanabe H, Uesaka T, Kido S, et al. Influence of concomitant miso or NaCl treatment on induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in rats[J]. Oncol Rep, 1999, 6(5): 989-993.
[59] Yu D, Shin HS, Lee YS, et al. Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1[J]. Oncol Rep, 2014, 31(2): 673-678.
[60] Benedek B, Weniger B, Parejo I, et al. Antioxidant activity of isoflavones and biflavones isolated from Godoya antioquiensis[J]. Arzneimittel-forschung, 2006, 56(9): 661-664.
[61] Rufer CE, Kulling SE. Antioxidant activity of isoflavones and their major metabolites using different in vitro assays[J]. J Agric Food Chem, 2006, 54(8): 2926-2931.
[62] Ruiz-Larrea MB, Mohan AR, Paganga G, et al. Antioxidant activity of phytoestrogenic isoflavones[J]. Free Radic Res, 1997, 26(1): 63-70.
[63] Yanagihara K, Ito A, Toge T, et al. Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract[J]. Cancer Res, 1993, 53(23): 5815-5821.
[64] Namuslu M, Kocaoglu H, Celik HT, et al. Effects of aqueous soybean, mistletoe and red clover extracts on activities of adenosine deaminase and xanthine oxidase enzymes[J]. Bratisl Lek Listy, 2014, 115(6): 367-371.
[65] Rekha CR, Vijayalakshmi G. Influence of natural coagulants on isoflavones and antioxidant activity of tofu[J]. J Food Sci Technol, 2010, 47(4): 387-393.
[66] Rodriguez-Roque MJ, Rojas-Grau MA, Elez-Martinez P, et al. Soymilk phenolic compounds, isoflavones and antioxidant activity as affected by in vitro gastrointestinal digestion[J]. Food Chem, 2013, 136(1): 206-212.
[67] 渡边敦光, 李艳芳, 李丽特. 豆酱(日本味噌)含盐量对胃癌及血压的影响[J]. 中国粮油学报, 2012, 27(4): 20-24. Hiromitsu Wastanabe, LI Yanfang, LI Lite. Effect of sodium chloride in Miso(Japanese soybean paste)on gastric cancer and blood pressure[J]. Journal of the Chinese Cereals and Oils Association, 2012, 27(4): 20-24.
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