山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (5): 30-39.doi: 10.6040/j.issn.1671-7554.0.2021.0272
罗兵*(
)
Bing LUO*()
摘要：
EB病毒(EBV)是一种重要的人类肿瘤病毒，与多种肿瘤的发生密切相关，其中包括约10%的胃癌。EBV在胃癌发生发展中的作用日益受到重视，被认为是除幽门螺杆菌外的另一个致病因素。EBV相关胃癌(EBVaGC)的一个重要特征是病毒和宿主基因组的广泛甲基化，仅表达有限的病毒基因，如EBV核抗原1、EBV编码的小RNA、Bam HI-A右转录本、潜伏膜蛋白2A和miRNAs。宿主细胞中与肿瘤相关的基因也受到广泛的影响。EBV感染是EBVaGC发生的重要表观遗传驱动因素。本综述讨论了EBV对EBVaGC宿主表观遗传学改变的影响及其在肿瘤发生过程中的作用。
中图分类号:
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