山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (9): 22-29.doi: 10.6040/j.issn.1671-7554.0.2021.0937
马燕燕,龚瑶琴
MA Yanyan, GONG Yaoqin
摘要： 人脑类器官是由人多能干细胞(hPSC)包括人胚胎干细胞(hESC)和人诱导多功能干细胞(hiPSC)衍生而来的三维组织,能模拟人大脑的结构和功能,作为神经发育疾病的体外研究模型独具优势。本文将对神经疾病体外模型建立和发展的历程、脑类器官在神经发育疾病研究中的应用、相关前沿技术和脑类器官技术的结合等进行综述和展望。
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