周期性张应力在冠状动脉旁路移植术后移植静脉内膜增生机制和治疗中的研究进展

doi:10.6040/j.issn.1671-7554.0.2025.0340

摘要/Abstract

摘要： 移植静脉内膜增生是冠状动脉旁路移植术后常见的并发症,但其发生机制和防治策略尚不完全清楚。周期性张应力作为一种血管壁所受的机械力刺激,在静脉移植后会显著升高。升高的周期性张应力通过表观遗传机制影响各类基因表达产物的含量,同时调节细胞的各类生物学功能,最终导致内膜增生的发生。本文阐述了周期性张应力在静脉移植后内膜增生中的作用机制和干预措施,为内膜增生的防治提供了新的视角。

关键词: 周期性张应力, 冠状动脉旁路移植术, 静脉移植, 内膜增生, 表观遗传

Abstract: Intimal hyperplasia of vein graft is a common complication after coronary artery bypass grafting, but the mechanism and prevention strategies of intimal hyperplasia are not fully understood. The cyclic stretch, as a mechanical force stimulation on the vascular wall, was significantly increased after vein graft. The elevated cyclic stretch could affect the content of various gene expression products through epigenetic mechanisms, while regulating various biological functions of cells, ultimately leading to the occurrence of intimal hyperplasia. This article elaborated on the mechanism and intervention measures of cyclic stretch in intimal hyperplasia after vein graft to provide a new perspective for the prevention and treatment of intimal hyperplasia.

Key words: Cyclic stretch, Coronary artery bypass graft, Vein graft, Intimal hyperplasia, Epigenetics

中图分类号:

R654

齐在文,白霄,秦源. 周期性张应力在冠状动脉旁路移植术后移植静脉内膜增生机制和治疗中的研究进展[J]. 山东大学学报 (医学版), 2025, 63(12): 118-124.

QI Zaiwen, BAI Xiao, QIN Yuan. Research progress on the mechanism and intervention strategies of cyclic stretch in the intimal hyperplasia after vein graft in coronary artery bypass grafting[J]. Journal of Shandong University (Health Sciences), 2025, 63(12): 118-124.

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