ApoE基因多态性与缺血性脑血管病患者脑微出血的相关性

doi:10.6040/j.issn.1671-7554.0.2018.1427

摘要/Abstract

摘要： 目的研究缺血性脑血管病患者脑微出血(CMBs)与载脂蛋白E(ApoE)基因多态性的相关性。方法随机选取2016年11月至2018年11月在贵州医科大学附属医院神经内科住院的诊断为缺血性脑血管病的130例患者为研究对象,通过磁敏感加权成像(SWI)检测结果分为有CMBs组和无CMBs组。收集患者临床资料及相关检验结果,并通过聚合酶链式反应-限制性核酸内切酶片段长度多态性法(PCR-RFLP)进行ApoE基因分型。结果无CMBs组与有CMBs组ApoE基因表型及等位基因分布差异有统计学意义(P<0.05)。Logistic回归分析结果显示, ApoE ε4基因携带组(OR:3.628,95%CI: 1.214~10.839)、男性(OR:3.287,95%CI: 1.209~8.934)、颈动脉粥样硬化(OR:4.401,95%CI: 1.614~12.005)是缺血性脑血管病发生脑微出血的独立危险因素。与非ε4基因携带组相比ε4基因携带组增加了脑叶微出血发生率。结论 ApoE 基因多态性与缺血性脑血管发生脑微出血具有一定相关性,ε4基因携带组增加脑微出血风险。

关键词: 载脂蛋白E, 基因多态性, 脑微出血, 缺血性脑血管病, 磁敏感加权成像

Abstract: Objective To investigate the association between apolipoprotein E genotype(ApoE)and cerebral microbleeds(CMBs)in ischemic cerebrovascular. Methods A total of 130 ischemic cerebrovascular patients treated in our hospital during Nov. 2016 and Nov. 2018 were randomly selected and divided into the CMBs group and non-CMBs group according to the results of susceptibility-weighted imaging(SWI). Clinical information and related laboratory tests were collected. The genotypes of ApoE were determined with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Results There were statistical differences in the frequency distributions of ApoE genotypes and alleles between the CMBs group and non-CMBs group (P<0.05). Logistic regression analysis showed that ApoE ε4 carrier (OR: 3.628, 95%CI 1.214~10.839), male (OR: 3.287, 95%CI 1.209~8.934) and carotid atherosclerosis (OR: 4.401, 95%CI 1.614~12.005) were the independent risk factors for CMBs. ApoE ε4 carriers had higher possibility of developing lobar CMBs. Conclusion Apolipoprotein E gene polymorphism is associated with cerebral microbleeds in ischemic cerebrovascular. ApoE ε4 carriers are more likely to develop CMBs than non-carriers.

Key words: Apolipoprotein E, Polymorphism, Cerebral microbleeds, Ischemic cerebrovascular, Susceptibility-weighted imaging

中图分类号:

R743

宋雨,田淑芬. ApoE基因多态性与缺血性脑血管病患者脑微出血的相关性[J]. 山东大学学报 (医学版), 2019, 57(4): 47-51.

SONG Yu, TIAN Shufen. Association between apolipoprotein E gene polymorphism and cerebral microbleeds in ischemic cerebrovascular patients[J]. Journal of Shandong University (Health Sciences), 2019, 57(4): 47-51.

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