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山东大学学报 (医学版) ›› 2018, Vol. 56 ›› Issue (7): 51-56.doi: 10.6040/j.issn.1671-7554.0.2017.1267

• • 上一篇    

PSMD6基因rs831571位点多态性与2型糖尿病易感性的病例对照研究

田忠艳1,李玉倩2,刘晓田1,史园园1,张海庆1,张霞1,千新玲1,尹磊3,赵景志3,王重建1   

  1. 1.郑州大学公共卫生学院流行病学教研室, 河南 郑州 450001;2.郑州大学药学院临床药理学系, 河南 郑州 450001;3.河南省军区直属医院体检中心, 河南 郑州 450003
  • 发布日期:2022-09-27
  • 通讯作者: 李玉倩. E-mail:liyuqian0214@126.com
  • 基金资助:
    国家自然科学基金(81602925,81573243);国家重点研发计划“精准医学研究”重点专项(2016YFC0900803);河南省科技创新人才支持计划(164100510021);河南省高校科技创新人才支持计划(14HASTIT035);河南省医学科技攻关计划(201401002,201403002);郑州大学高端人才支持计划(ZDGD13001)

Relationship between PSMD6 gene rs831571 locus polymorphism and the susceptibility of T2DM: a case-control study

TIAN Zhongyan1, LI Yuqian2, LIU Xiaotian1, SHI Yuanyuan1, ZHANG Haiqing1, ZHANG Xia1, QIAN Xinling1, YIN Lei3, ZHAO Jingzhi3, WANG Chongjian1   

  1. 1. Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China;
    2. Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China;
    3. Department of Health Care, Military Hospital in Henan, Zhengzhou 450003, Henan, China
  • Published:2022-09-27

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摘要： 目的 探讨PSMD6基因rs831571位点多态性与河南汉族人群2型糖尿病(T2DM)易感性的关系以及基因-环境危险因素的交互作用。 方法 研究对象来自“农村糖尿病、肥胖及生活方式”研究。从中选取T2DM患者1 052例,作为T2DM组,按年龄(±3岁)同性别进行1∶1匹配;选取非T2DM患者1 052例,作为对照组。使用SNPscanTM高通量SNP分型技术对PSMD6基因rs831571位点进行分型。采用Logistic回归分析基因多态性与T2DM的关联强度及PSMD6基因-环境危险因素对T2DM的交互作用。 结果 T2DM组和对照组PSMD6基因rs831571位点基因型频率分布差异有统计学意义(P<0.05)。调整相关影响因素后,rs831571位点TT(OR=0.623, 95%CI: 0.456~0.853)和CT+TT(OR=0.825, 95%CI: 0.685~0.995)基因型携带者T2DM易感性降低。联合作用结果显示,携带PSMD6突变基因型且中重度体力活动者或携带PSMD6突变基因型且BMI正常者,T2DM的患病风险降低,但PSMD6基因-体力活动以及PSMD6基因-BMI在T2DM的发生中没有交互作用(P>0.05)。 结论 PSMD6基因rs831571位点多态性与T2DM易感性有关,携带PSMD6突变基因型且中重度体力活动者或携带PSMD6突变基因型且BMI正常者,T2DM的患病风险降低,PSMD6基因-体力活动以及基因-BMI对T2DM的发生无交互作用。

关键词: 2型糖尿病, PSMD6基因多态性, 环境危险因素, 交互作用

Abstract: Objective To explore the relationship between PSMD6 gene rs831571 locus polymorphism and the susceptibility of type 2 diabetes mellitus(T2DM)in Henan Han population, and to assess interaction between PSMD6 gene rs831571 locus polymorphism and environmental risk factors. Methods The participants were derived from the Rural 山 东 大 学 学 报 (医 学 版)56卷7期 -田忠艳,等.PSMD6基因rs831571位点多态性与2型糖尿病易感性的病例对照研究 \=-Diabetes, Obesity and Lifestyle(RuralDiab)study in China. A total of 1 052 patients with T2DM(T2DM group)and 1 052 participants without T2DM(control group)were included in the present study after a 1∶1 match based on the age and gender. A custom-by-design 2×48-Plcx SNPscanTM Kit was applied to determine the genotypes of PSMD6 gene rs831571 locus. Logistic regression model was performed to estimate the association between T2DM and PSMD6 gene polymorphism and evaluate the interaction of PSMD6 gene-environmental risk factors. Results Significant difference was observed in the genotype frequencies of PSMD6 gene rs831571 locus in T2DM and control groups(P<0.05). After adjusting smoking, drinking, etc, the genotypes TT(OR=0.623, 95%CI: 0.456-0.853)and CT+TT(OR=0.825, 95%CI: 0.685-0.995)of PSMD6 gene rs831571 locus polymorphism decreased the susceptibility of T2DM. Combined effects analysis revealed that mutant type of MSPD6 with normal BMI or moderate or severe physical activity could attenuate the risk of T2DM, but PSMD6 gene-physical activity and PSMD6 gene-BMI interaction analysis was of no statistical significance(P>0.05). Conclusion PSMD6 gene rs831571 locus polymorphism is associated with the susceptibility of T2DM. In addition, mutant type of PSMD6 with normal BMI or moderate or severe physical activity can attenuate the risk of T2DM. The interactions of PSMD6 gene-physical activity and PSMD6 gene-BMI on T2DM present no statistical significance.

Key words: Type 2 diabetes mellitus, PSMD6 gene polymorphism, Environmental risk factors, Interaction

中图分类号: 

  • R181
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