山东大学学报（医学版） ›› 2017, Vol. 55 ›› Issue (5): 95-102.doi: 10.6040/j.issn.1671-7554.0.2016.1196
杜金阁1,陈慧2,杨孝荣1,吕明1,2
DU Jinge1, CHEN Hui2, YANG Xiaorong1, LÜ Ming1,2
摘要： 目的 通过Meta分析探讨信号转导和转录激活因子4(STAT4)基因rs7574865位点单核苷酸多态性(SNP)与系统性红斑狼疮(SLE)易感性之间的关系。 方法 两名研究者分别检索PubMed、Web of science、Scopus、中国知网和万方数据库,筛选出相关文献。用合并OR值和95% CI评价STAT4 rs7574865位点SNP与SLE易感性之间的关系。 结果 共纳入27篇研究,包含21 902例SLE患者和37 780例对照。Meta分析结果如下:等位基因模型(T vs G, OR=1.56, 95% CI:1.49~1.63),纯合子模型(TT vs GG, OR=2.32, 95% CI:2.08~2.58),杂合子模型(TG vs GG, OR=1.52, 95% CI:1.41~1.64),显性遗传模型(TT/TG vs GG, OR=1.67, 95% CI:1.55~1.79),隐性遗传模型(TT vs TG/GG, OR=1.83, 95% CI:1.65~2.02)。按研究对象所在的地区进行亚组分析后显示,所有亚组中,rs7574865 SNP均与SLE易感性有关。 结论 STAT4 rs7574865位点SNP与SLE的易感性有关,T等位基因的存在增加SLE的患病风险。
中图分类号:
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