高尿酸血症、幽门螺杆菌感染与代谢综合征的相关性

doi:10.6040/j.issn.1671-7554.0.2017.191

摘要/Abstract

摘要： 目的探讨高尿酸血症(HUA)、幽门螺杆菌(Hp)感染与代谢综合征(MS)的相关性,为制定降低MS患病率的医疗卫生措施提供流行病学证据。方法采用横断面研究法选取2015年1月至2015年12月山东大学齐鲁医院体检中心符合入选标准的体检人群8 541例,其中男5 117例,女3 424例, 20~80岁,平均(47.99±11.95)岁。依据中华医学会糖尿病学分会(CDS)建议的诊断标准,分为MS组(n=1 442例)和非MS组(n=7 099例)。C-13呼气试验检测Hp及空腹血生化检查。按照年龄分为青年组(≤44岁)、中年组(45~59岁)和老年组(≥60岁)。根据血尿酸(SUA)水平分为正常SUA组和HUA组。Hp分为Hp感染(Hp+)组和Hp未感染(Hp-)组。按照SUA水平及Hp感染情况分为Hp-正常SUA组、Hp+正常SUA组、Hp-HUA组和Hp+HUA组。分析SUA、Hp感染与MS患病的关系。结果 MS组患病率男22.1%,女9.0%,差异有统计学意义(P<0.05);MS组年龄、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、甘油三酯(TG)、HUA均高于非MS组(P<0.05),Hp+高于非MS组(P=0.021),高密度脂蛋白(HDL-C)低于非MS组(P<0.05);性别、年龄与Hp感染无关,与HUA、MS患病相关,差异有统计学意义(P<0.05);男性、女性中Hp感染与MS发生无关,HUA、Hp感染合并HUA增加MS患病率(P<0.05)。老年组Hp感染增加MS患病率(P<0.05),青年组、中年组、老年组中HUA、Hp感染合并HUA增加MS患病率(P<0.05)。结论性别、年龄与MS密切相关;HUA、 Hp感染可能是MS的危险因素。

关键词: 高尿酸血症, 幽门螺杆菌, 感染, 体检, 代谢综合征

Abstract: Objective To explore the correlation among serum uric acid(SUA), infection of helicobacter pylori (Hp)and metabolic syndrome(MS)in order to provide epidemiological evidences to reduce incidence of MS. Methods A cross-sectional study was conducted on 8 541 patients who met the inclusion standard, including 5 117 male and 3 424 female, aged 20~80(average 47.99±11.95)years. C-13 breath test-Hp and fasting blood biochemical examinations were conducted. The patients were divided into 2 groups, MS group(n=1 442)and non-MS(n=7 099), according 山东大学学报 (医学版)55卷5期 -于珍珍,等.高尿酸血症、幽门螺杆菌感染与代谢综合征的相关性 \=-to the diagnostic criteria issued by Chinese Diabetes Society(CDS). According to age, the patients were divided into 3 groups: youth group(≤ 44 years), middle-aged group(45-59 years)and elderly group(≥ 60 years). According to the level of SUA, the patients were divided into SUA group and hyperuricemia(HUA)group. According to Hp status, the patients were divided into Hp+ and Hp- groups. According to the combination of SUA and HUA, the patients were divided into Hp- SUA, Hp+ SUA, Hp- HUA, and Hp+ HUA groups. The relationship between SUA, Hp infection and MS was analyzed with odds ratio and chi-square test. Results In the MS group, the male and female incidence rate was 22.1% and 9.0%, respectively, with statistical difference(P<0.05). The body mass index(BMI), systolic pressure(SBP), diastolic pressure(DBP), fasting blood glucose(FBG), triglyceride(TG)and Hp+ of MS group were higher than those of non-MS group(P<0.05), while high-density lipoprotein cholesterol(HDL-C)was lower than that of non-MS(P<0.001). Sex, age and Hp infection were related to HUA and MS, but not to MS(P<0.05). In both male and female groups, Hp infection was not related to MS; HUA and HUA complicated with Hp infection increased the incidence of MS(P<0.05). Hp infection increased the incidence of MS in the elderly group(P<0.05); HUA and HUA complicated with Hp infection increased the incidence of MS in all age groups(P<0.05). Conclusion Gender and age are closely related to MS; HUA and Hp infection are risk factors of MS.

Key words: Hyperuricemia, Helicobacter pylori, Metabolic syndrome, Infection, Physical examination

中图分类号:

R181.3

于珍珍,陈慧,杨晓云,吕明. 高尿酸血症、幽门螺杆菌感染与代谢综合征的相关性[J]. 山东大学学报（医学版）, 2017, 55(5): 76-80.

YU Zhenzhen, CHEN Hui, YANG Xiaoyun, LÜ Ming. Correlation between hyperuricemi, Helicobacter pylori infection and metabolic syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 76-80.

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