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山东大学学报（医学版） ›› 2017, Vol. 55 ›› Issue (5): 81-85.doi: 10.6040/j.issn.1671-7554.0.2016.1676

• 临床医学 • 上一篇    下一篇

来曲唑治疗不同体质量指数多囊卵巢综合征患者的临床效果

张素萍1,2,王泽1,周亚丽3, 李敬1,路西兰4,柏宏伟4,石玉华1   

  1. 1.山东大学附属生殖医院生殖科, 山东 济南 250001;2.邹城市人民医院妇科, 山东 邹城 273500;3.曹县县立医院妇产科, 山东 曹县 274400;4. 济南市中心医院生殖医学科, 山东 济南 250013
  • 收稿日期:2016-12-19 出版日期:2017-05-10 发布日期:2017-05-10
  • 通讯作者: 石玉华. E-mail:shiyuhua2003@126.com E-mail:shiyuhua2003@126.com
  • 基金资助:
    国家自然基金面上项目(81471428,81200423);山东省医药卫生科技发展计划项目(2014WS0122);山东省科技发展计划项目(2014GSF118148)

Clinical effects of body mass index on ovulation induction treatment with letrozole among women with polycystic ovary syndrome

ZHANG Suping1,2, WANG Ze1, ZHOU Yali3, LI Jing1, LU Xilan4, BAI Hongwei4, SHI Yuhua1   

  1. 1. Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan 250001, Shandong, China;
    2. Department of Gynaecology, Zoucheng Peoples Hospital, Zoucheng 273500, Shandong, China;
    3. Department of Obstertrics and Gynecology, Caoxian County Hospital, Caoxian 274400, Shandong, China;
    4. Center for Reproductive Medicine, Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2016-12-19 Online:2017-05-10 Published:2017-05-10

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摘要： 目的 比较不同体质量指数(BMI)的多囊卵巢综合征(PCOS)患者使用来曲唑促排卵的临床效果。 方法 将2014年1月至2015年12月于山东大学附属生殖医院就诊的153例有生育要求的PCOS患者作为研究对象,根据BMI将患者分为肥胖型组71例和非肥胖型组82例。在患者月经第2~4天开始给予来曲唑5 mg,次/d×5 d促排卵监测并指导同房;比较两组间的促排卵效果。 结果 肥胖型组的血糖、胰岛素、甘油三酯、高密度脂蛋白及总胆固醇水平高于非肥胖型组(P=0.020, <0.001, 0.002, <0.001, 0.028),而给予绒促性素(HCG)日雌二醇水平低于非肥胖型组,差异均有统计学意义(P=0.026)。两组患者的优势卵泡数、排卵率、HCG日子宫内膜厚度和促黄体生成素、孕酮等激素水平、妊娠率、流产率及活产率等的比较差异均无统计学意义(P>0.05)。 结论 不同BMI的PCOS患者可选用来曲唑促排卵,其可提高周期排卵率及妊娠率,肥胖型PCOS患者临床效果与非肥胖型患者相似。

关键词: 活产率, 多囊卵巢综合征, 来曲唑, 体质量指数, 肥胖

Abstract: Objective To compare the clinical effects of body mass index(BMI)on ovulation induction treatment with letrozole among women with polycystic ovary syndrome(PCOS). Methods A total of 153 infertile PCOS women treated during Jan. 2014 and Dec. 2015 were enrolled. These women were divided into obese group(n=71)and non-obese group(n=82)according to their BMI. The stimulation was initiated by letrozole at a dose of 5mg daily for 5 days, beginning from day 2 to day 4 of the menstrual cycle. The ovulation induction outcomes of the two groups were compared. Results The obese group had significantly higher serum glucose, insulin, triglyceride, high density lipoprotein(HDL), and total cholesterol level than the non-obese group(P=0.020, <0.001, =0.002, <0.001, =0.028). On the day when human chorionic gonadotropin(HCG)was administered, estradiol(E2)was statistically lower in the obese group than in the non-obese group(P=0.026). There were no differences in the number of dominant follicles, ovulation rate, luteinizing hormone(LH)level on the HCG day, progesterone level, pregnancy rate, miscarriage rate and live birth rate between the two groups(P>0.05). Conclusion Letrozole is an effective ovulation induction agent for infertile PCOS women with different MBI by improving the ovulation and pregnancy rate.

Key words: Polycystic ovary syndrome, Letrozole, Body mass index, Live birth rate, Obesity

中图分类号: 

  • R588
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