您的位置:山东大学 -> 科技期刊社 -> 《山东大学学报(医学版)》

山东大学学报(医学版) ›› 2016, Vol. 54 ›› Issue (1): 86-91.doi: 10.6040/j.issn.1671-7554.0.2015.535

• 临床医学 • 上一篇    下一篇

东营市某三甲医院纵向体检资料的血清谷丙转氨酶水平与代谢综合征的相关性

肖娟1*, 陈启才2*,张鹏鹏3,陈莉莉4,陈潇潇1,王束玫1   

  1. 1. 山东大学公共卫生学院流行病学系, 山东 济南 250012;
    2. 胜利油田中心医院体检中心, 山东 东营 257000;
    3. 天津市出入境检验检疫局保税区办事处检务科, 天津 300000;
    4. 浙江省疾病预防控制中心营养与食品安全所, 浙江 杭州 310051
  • 收稿日期:2015-05-30 出版日期:2016-01-11 发布日期:2016-01-11
  • 通讯作者: 王束玫. E-mail: wshm@sdu.edu.cn*共同第一作者 E-mail:wshm@sdu.edu.cn

Association between serum alanine transaminase with metabolic syndrome and its components based on a longitudinal health check-up study in Dongying City, China

XIAO Juan1*, CHEN Qicai2*, ZHANG Pengpeng3, CHEN Lili4, CHEN Xiaoxiao1, WANG Shumei1   

  1. 1. Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Health Examination Center, Central Hospital of Shengli Oilfield, Dongying 257000, Shandong, China;
    3. Department of Supervision, Tax-protected Zone Office, Tianjin Entry-Exit Inspection and Quarantine Bureau, Tianjin 300000, China;
    4. Department of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China
  • Received:2015-05-30 Online:2016-01-11 Published:2016-01-11

摘要: 目的 探讨基线拥有不同代谢综合征(MS,包括高血压、超重或肥胖、高脂血症和高血糖4个组分)组分个数的人群血清谷丙转氨酶(ALT)与MS的关系。 方法 基于东营市某三甲医院纵向体检资料构建2006年1月至2011年12月动态体检队列,选取未患MS且至少有3次完整体检资料的5 122名调查对象纳入基线,并根据研究对象拥有MS组分个数的不同(0~2个)进行分层,建立多因素广义估计方程模型(GEE),分析ALT(四分位数间距)与MS发生的相关性,计算RR值及95%CI。 结果 血清ALT水平的升高与MS及其组分的发生呈正相关。与ALT最低水平组相比,基线有0~2个MS组分的人群ALT最高水平组与MS发生的RR值依次为4.39(2.26~8.52)、6.97(3.37~14.42)和1.93(1.26~2.95),基线0个MS组分和仅有1个MS组分的研究对象高水平血清ALT对MS发生的预测性高于基线有2个MS组分的研究对象。 结论 高水平ALT对MS的发生有一定预测性,并在代谢状况不同的人群中有不同表现,血清ALT水平的升高可能是MS发生的早期标志物。

关键词: 谷丙转氨酶, 代谢综合征, 广义估计方程, 东营市, 动态体检队列

Abstract: Objective To investigate the association of serum alanine aminotransferase(ALT)with metabolic syndrome(MS, including hypertension, obesity, hyperlipidemia and hyperglycemia)categorized by different numbers of MS components at baseline. Methods A dynamic health examination cohort study was conducted during 2006 and 2011, which included 5 122 participants who satisfied two basic rules: being free of MS at 1st health check, and having at least three complete health checks. With generalized estimating equation(GEE)model, multivariable relative risk 山 东 大 学 学 报 (医 学 版)54卷1期 -肖娟,等.东营市某三甲医院纵向体检资料的血清谷丙转氨酶水平与代谢综合征的相关性 \=-(RRs)of time-varying ALT with MS and its components were analyzed. Results Increased serum ALT was positively associated with MS and its components. Compared with Q1, RRs(Q4 of ALT for MS)of participants with 0-2 components at baseline were 4.39(2.26-8.52), 6.97(3.37-14.42)and 1.93(1.26-2.95), respectively. Elevated ALT showed stronger predictability for MS in participants with 0 or 1 component of MS than participants with 2 components. Conclusion Elevated serum ALT is an early biomarker of MS and its components. Especially, it may increase the risk of MS in participants with 0 or 1 component of MS.

Key words: Alanine aminotransferase, Generalized estimating equation, Dynamic health examination cohort, Metabolic syndrome, Dongying City

中图分类号: 

  • R589.1
[1] Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome:a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity[J]. Circulation, 2009, 120(16):1640-1645.
[2] Chen S, Guo X, Zhang X, et al. Association between elevated serum alanine aminotransferase and cardiometabolic risk factors in rural Chinese population: a cross-sectional study[J]. BMC Cardiovasc Disord, 2015, 15:65. doi: 10.1186/s12872-015-0060-y.
[3] 贾堂宏, 侯廷成, 谢忠元, 等. 济南市社区人群代谢综合征检出率及危险因素调查[J]. 山东大学学报(医学版), 2013, 51(7):96-99. JIA Tanghong, HOU Tingcheng, XIE Zhongyuan, et al. Epidemiologic survey of metabolic syndrome and its related risk factors in Jinan community population[J]. Journal of Shandong University(Health Science), 2013, 51(7):96-99.
[4] Azzam H, Malnick S. Non-alcoholic fatty liver disease-the heart of the matter[J]. World J Hepatol, 2015, 7(10):1369-1376.
[5] 齐婷, 刘彦君, 许樟荣, 等. 2型糖尿病患者正常值范围内的较高血清谷丙转氨酶与心血管危险因素簇集的相关性研究[J]. 中国糖尿病杂志, 2012, 20(1):51-54. QI Ting, LIU Yanjun, XU Zhangrong, et al. Association of the higher alanine aminotransferase level in the normal range with cardiovascular risk clusters in the patients with T2DM[J]. Chinese Journal of Diabetes, 2012, 20(1):51-54.
[6] Lee K, Yang JH. Which liver enzymes are better indicators of metabolic syndrome in adolescents: the fifth Korea national health and nutrition examination survey, 2010[J]. Metab Syndr Relat Disord, 2013, 11(4):229-235.
[7] Sitlani CM, Rice KM, Lumley T, et al. Generalized estimating equations for genome-wide association studies using longitudinal phenotype data[J]. Stat Med, 2015, 34(1):118-130.
[8] WHO. Guidelines for controlling and monitoring the tobacco epidemic[M]. World Health Organization, 1998.
[9] 马冠生, 朱丹红, 胡小琪, 等. 中国居民饮酒行为现况[J]. 营养学报, 2005, 27(5):362-365. MA Guansheng, ZHU Danhong, HU Xiaoqi, et al. The drinking practice of people in China[J]. Acta Nutrimenta Sinica, 2005, 27(5):362-365.
[10] 中华医学会糖尿病分会代谢综合征研究协作组. 中华医学会糖尿病学分会关于代谢综合征的建议[J]. 中华糖尿病杂志, 2004, 12(3):156-160.
[11] 崔继烨, 侯立君, 张丽莉, 等. 代谢综合征与谷丙转氨酶关系的调查研究[J]. 保健医学研究与实践, 2011, 8(2):16-18. CUI Jihua, HUO Lijun, ZHANG Lili, et al. A Study of the relationship between MS and ALT[J]. Health Medicine Research and Practice, 2011, 8(2):16-18.
[12] Liu Z, Que S, Ning H, et al. Elevated alanine aminotransferase is strongly associated with incident metabolic syndrome:a meta-analysis[J]. PLoS One, 2013, 8(12):e80596. doi: 10.1371/journal.pone.0080596. eCollection 2013.
[13] Evans S, Li L. A comparison of goodness of fit tests for the logistic GEE model[J]. Stat Med, 2005, 24(8):1245-1261.
[14] Hsieh MH, Ho CK, Hou NJ, et al. Abnormal liver function test results are related to metabolic syndrome and BMI in Taiwanese adults without chronic hepatitis B or C[J]. Int J Obes(Lond), 2009, 33(11):1309-1317.
[15] Saki F, Karamizadeh Z. Metabolic syndrome, insulin resistance and fatty liver in obese Iranian children[J]. Iran Red Crescent Med J, 2014, 16(5): e6656. doi: 10.5812/ircmj.6656. Epub 2014 May 5.
[16] Singh AK, Tiwari S, Gupta A, et al. Association of resistin with insulin resistance and factors of metabolic syndrome in north Indians[J]. Indian J Clin Biochem, 2015, 30(3):255-262.
[17] Pei D, Hsia TL, Chao TT, et al. γ-glutamyl transpeptidase in men and alanine aminotransferase in women are the most suitable parameters among liver function tests for the prediction of metabolic syndrome in nonviral hepatitis and nonfatty liver in the elderly[J]. Saudi J Gastroenterol, 2015, 21(3):158-164.
[1] 扈艳雯,王志媛,郁万江,赵蕙琛,韩合理,徐志鹏,马红,张玉超,刘元涛. 52例肥胖患者脂肪分布与代谢综合征及糖代谢指标的相关性[J]. 山东大学学报 (医学版), 2020, 1(8): 101-106.
[2] 孙苑潆,杨亚超,曲明苓,陈雁敏,李敏,王淑康,薛付忠,刘云霞. 健康管理人群代谢综合征发病风险预测模型[J]. 山东大学学报(医学版), 2017, 55(6): 87-92.
[3] 于珍珍,陈慧,杨晓云,吕明. 高尿酸血症、幽门螺杆菌感染与代谢综合征的相关性[J]. 山东大学学报(医学版), 2017, 55(5): 76-80.
[4] 许艺博,季晓康,李向一,申振伟,薛付忠. 尿液pH与代谢综合征的相关性[J]. 山东大学学报(医学版), 2016, 54(12): 82-85.
[5] 刘言训, 刘佳, 张涛, 王璐, 薛付忠, 王萍. 基于纵向监测队列的2型糖尿病与甲状腺结节的关联性[J]. 山东大学学报(医学版), 2015, 53(8): 83-86.
[6] 张风雷, 郑曼, 张琦, 顾磊, 徐新生. 代谢综合征与P波离散度关系的探讨[J]. 山东大学学报(医学版), 2015, 53(2): 52-55.
[7] 王光亚, 郭宁宁, 赵乃蕊, 李瑞杰, 高书明. 脂联素水平在2型糖尿病和甲状腺疾病中的变化及意义[J]. 山东大学学报(医学版), 2014, 52(S1): 96-97.
[8] 靳成伟, 李葵, 赵静, 岳欣, 尚嫄嫄, 韩露, 张运, 张薇, 马骁, 钟明. 外周血单核细胞甘油三酯水解酶的表达与代谢综合征的相关性[J]. 山东大学学报(医学版), 2014, 52(8): 39-42.
[9] 刘聪聪1,祝筠2,宋翠玲3,刘平4. 济南市某医院健康查体人群代谢综合征与血清胆红素的相关性[J]. 山东大学学报(医学版), 2014, 52(3): 101-105.
[10] 贾堂宏1,侯廷成1,谢忠元1,窦克宏1,张济2,边学峰2,时延申3,牛纪伦4,杨华5. 济南市社区人群代谢综合征检出率及危险因素调查[J]. 山东大学学报(医学版), 2013, 51(7): 100-106.
[11] 武传龙1,许良银2,侯新国1,赵汝星1,陈丽1. 甲状腺功能与肥胖及代谢综合征的相关性分析[J]. 山东大学学报(医学版), 2013, 51(12): 88-91.
[12] 韩露1,王彬2,牟晓梅2,巩会平3,闫会敏1,王志浩1,张运1,张薇1,钟明1. 代谢综合征患者心脏损害与脂肪因子变化的临床研究[J]. 山东大学学报(医学版), 2011, 49(9): 63-.
[13] 闫会敏1,杨静2,巩会平1,3,王志浩1,方宁宁1,王佳1,张薇1,张运1,钟明1. TRB3基因+251A/G多态性与代谢综合征患者左房功能的相关性研究[J]. 山东大学学报(医学版), 2010, 48(7): 69-.
[14] 黄坤玲1,王立启2,朱世明2. 伴代谢综合征高血压患者微量白蛋白尿和血清高分子量脂联素的变化[J]. 山东大学学报(医学版), 2010, 48(4): 78-82.
[15] 孟媛媛,单培彦,刘爱芬,麻琳,程梅,戴廷军. 老年患者代谢综合征与轻度认知功能障碍的相关性研究[J]. 山东大学学报(医学版), 2010, 48(2): 14-.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!