非小细胞肺癌患者血清肝癌衍生生长因子、血管内皮生长因子的水平及意义

doi:10.6040/j.issn.1671-7554.1.2014.008

摘要/Abstract

摘要： 目的探讨肝癌衍生生长因子（HDGF）、血管内皮生长因子（VEGF）在非小细胞肺癌（NSCLC）患者血清中的表达及意义。方法选择非小细胞肺癌患者30例为肺癌组，良性肺部疾病患者30例为良性肺病组，健康人30例为对照组。比较各组血清HDGF、VEGF水平，分析肺癌组患者血清HDGF、VEGF水平的相关因素，对肺癌组患者血清HDGF、VEGF水平进行相关性分析。结果良性肺病组血清HDGF水平高于对照组（P<0.01），VEGF水平低于对照组（P<0.01）。肺癌组血清HDGF、VEGF水平高于对照组（P<0.01）；HDGF水平低于良性肺病组（P<0.01），VEGF水平高于良性肺病组（P<0.01）。肺癌组血清HDGF、VEGF水平与性别、年龄无统计学相关，与吸烟、病理类型、分化程度、病理分期、淋巴结转移密切相关。肺癌组患者血清HDGF、VEGF水平呈正相关（r=0.33， P<0.01）。结论血清HDGF水平与肺癌分期密切相关，血清VEGF水平、淋巴结状态与肺癌分期密切相关，二者对NSCLC患者病程的判定有一定帮助。

关键词: 血管内皮生长因子, 血清, 非小细胞肺, 癌, 肝癌衍生生长因子

Abstract: Objective To explore the expressions and significances of serum hepatic cancer-derived growth factor (HDGF) and vascular endothelial growth factor (VEGF) in patients with non-small cell lung cancer (NSCLC). Methods A total of 30 patients with NSCLC served as NSCLC group while other 30 patients with benign lung disease as benign lung disease group, and 30 healthy people as control group. Serum HDGF and VEGF levels were compared among the three groups and analyzed in NSCLC group for their relevant factors and relationship. Results Benign lung disease group was evidently higher in serum HDGF level and lower in VEGF level than control group (P<0.01), while NSCLC group was obviously higher than control group in both HDGF and VEGF levels (P<0.01). However, NSCLC group was markedly lower in HDGF level but higher in VEGF level than benign lung disease group (P<0.01). Serum HDGF and VEGF levels had no significant relationship with ages and genders in NSCLC group, but they had apparent association with smoking history, adeno-carcinoma, non- and low- differentiation, pathological stage and lymph node metastasis. Serum HDGF and VEGF levels were positively correlated(r=0.33, P<0.01). Conclusion Serum HDGF level has close association with clinical stages, and serum VEGF level is closely correlated with conditions of lymph nodes and clinical stages of lung cancers, so they are helpful in the diagnosis of NSCLC.

Key words: Hepatic cancer-derived growth factor, Serum, Vascular endothelial growth factor, Non-small cell lung cancer

中图分类号:

R734.2

袁志平, 牟华平, 陈佳莲, 邓黎. 非小细胞肺癌患者血清肝癌衍生生长因子、血管内皮生长因子的水平及意义[J]. 山东大学学报（医学版）, 2014, 52(9): 63-66.

YUAN Zhiping, MOU Huaping, CHEN Jialian, DENG Li. Expressions and significances of serum hepatic cancer-derived growth factor and vascular endothelial growth factor in patients with non-small cell lung cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(9): 63-66.

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