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山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (9): 58-62.doi: 10.6040/j.issn.1671-7554.0.2014.028

• 临床医学 • 上一篇    下一篇

血清CTRP9、APN水平与急性冠脉综合征的相关性

刘天骄1, 郭媛2, 李婷婷2, 张建宁3, 李俊1, 张鹏1   

  1. 1. 山东大学齐鲁医院 教育部和卫生部心血管重构与功能研究重点实验室, 山东 济南 250012;
    2. 山东大学齐鲁医院 心血管内科, 山东 济南 250012;
    3. 山东大学齐鲁医院 ICU, 山东 济南 250012
  • 收稿日期:2014-01-13 修回日期:2014-09-05 出版日期:2014-09-10 发布日期:2014-09-10
  • 基金资助:
    国家自然科学基金(81350025)

Association of serum CTRP9 and APN levels with acute coronary syndrome

LIU Tianjiao1, GUO Yuan2, LI Tingting2, ZHANG Jianning3, LI Jun1, ZHANG Peng1   

  1. 1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Department of ICU, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-01-13 Revised:2014-09-05 Online:2014-09-10 Published:2014-09-10
  • Contact: 郭媛。E-mail:guoyuan9092@163.com E-mail:guoyuan9092@163.com

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摘要： 目的 探讨血清C1q/肿瘤坏死因子相关蛋白9（CTRP9）、脂联素（APN）水平与急性冠脉综合征（ACS）及冠脉病变程度的关系及可能的作用机制。方法 结合临床表现和冠状动脉造影术（CAG）造影结果将61例冠心病（CHD）患者分为不稳定型心绞痛组（UAP组，n=18），急性心肌梗死组（AMI组，n=18），稳定型心绞痛组（SAP组，n=25），另取CAG检查无狭窄的正常对照组（CON组，n=26）。其中UAP组和AMI组合称为急性冠脉综合征组（ACS组），UAP组、AMI组和SAP组合称为冠心病组（CHD组）。采用酶联免疫吸附试验检测血清CTRP9、APN水平，同时检测血脂、血糖水平。采用Pearson相关分析和多元回归分析方法分析CTRP9、APN与ACS及冠脉病变程度的相关性。结果 CHD组APN水平显著低于对照组（P<0.05）；ACS组CTRP9水平显著低于对照组（P<0.01）和SAP组（P<0.05），APN水平显著低于对照组（P<0.01）；AMI组CTRP9水平显著低于SAP组（P<0.01）。血清CTRP9与APN正相关（r=0.742， P<0.01），与FPG负相关（r=0.592， P<0.01），在CHD组与HDL-C水平正相关（r=0.254， P<0.05）。血清CTRP9、APN与Gensini积分负相关（r=0.579、0.777， P均<0.01）。结论 CTRP9、APN与ACS及冠状动脉病变程度相关，能为ACS和冠脉病变程度的诊断与评估提供较便利的预测指标。

关键词: C1q/肿瘤坏死因子相关蛋白9, 冠心病, 急性冠脉综合征, 脂联素

Abstract: Objective To investigate the association of serum C1q/tumor necrosis factor related protein 9 (CTRP9) and adiponectin (APN) with acute coronary syndrome (ACS) and severity of coronary artery stenosis, and the potential mechanism. Methods A total of 61 patients with coronary heart disease(CHD) confirmed by coronary angiography (CAG) were divided into unstable angina pectoris group(UAP group, n=18), acute myocardial infarction group(AMI group, n=18), and stable angina pectoris group(SAP group, n=25). Healthy subjects without stenosis were as a control group(CON group, n=26). The UAP and AMI groups were dedined as acute coronary syndrome group (ACS group); the UAP, AMI and SAP groups were defined as coronary heart disease group(CHD goup). The serum levels of CTRP9 and APN were determined by enzyme-linked immunosorbent assay. The serum levels of lipids indexes and fasting plasma glucose(FPG)were also determined. The correlations of CTRP9 and APN with ACS and severity of coronary artery stenosis were analyzed with Pearson correlation analysis and multiple regression analysis. Results In CHD group, APN level was significantly lower than that in control group (P<0.01). In ACS group, CTRP9 level was significantly lower than those in control group (P<0.01) and SAP group (P<0.05). APN level was significantly lower than that in control group (P<0.01). In AMI group, CTRP9 level was significantly lower than that in SAP group (P<0.01). The serum CTRP9 level was positively correlated with APN (r=0.742, P<0.01) and negative correlated with FPG (r=0.592, P<0.01). CTRP9 level was only positively correlated with HDL-C level (r=0.254, P<0.05) in CHD group. Serum CTRP9 and APN levels were negatively correlated with Gensini score (r=0.579 and 0.777, P<0.01). Conclusion CTRP9 and APN are associated with ACS and the severity of coronary artery stenosis. It can provide a more convenient predictive target for the diagnosis and assessment of ACS and the severity of coronary artery disease.

Key words: C1q/tumor necrosis factor related protein 9, Coronary heart disease, Adiponectin, Acute coronary syndrome

中图分类号: 

  • R541.4
[1] Su H, Yuan Y, Wang X M, et al. Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice[J]. Basic Res Cardiol, 2013, 108(1): 1-12.
[2] 蒋婷婷, 陈星, 李婷婷, 等. 冠状动脉粥样硬化性心脏病8号染色体基因扫描[J]. 遗传, 2012, 34(8): 1043-1049. JIANG Tingting, CHEN Xing, LI Tingting, et al. Genetic scanning on chromosome 8 loci for coronary heart disease[J]. Hereditas, 2012, 34(8): 1043-1049.
[3] Kojima S, Kojima S, Maruyoshi H, et al. Hypercholes-terolemia and hypoadiponectinemia are associated with necrotic core-rich coronary plaque[J]. Int J Cardiol, 2011, 147(3): 371-376.
[4] Sawada T, Shite J, Shinke T, et al. Low plasma adi-ponectin levels are associated with presence of thin-cap fi-broatheroma in men with stable coronary artery disease[J]. Int J Cardiol, 2010, 142(3): 250-256.
[5] Iwata A, Miura S, Mori K, et al. Associations between metabolic factors and coronary plaque growth or arterial remodeling as assessed by intravascular ultrasound in patients with stable angina[J]. Hypertens Res, 2008, 31(10): 1879-1886.
[6] Li L, Cai X J, Feng M, et al. Effect of adiponectin over-expression on stability of preexisting plaques by inducing prolyl-4-hydroxylase expression[J]. Circ J, 2010, 74(3): 552-559.
[7] Margaritis M, Antonopoulos A S, Digby J, et al. Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels[J]. Circulation, 2013, 127(22): 2209-2221.
[8] Okamoto Y, Ishii S, Croce K, et al. Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques[J]. Atherosclerosis, 2012, 226(2013): 373-377.
[9] Wong G W, Krawczyk S A, Kitidis-Mitrokostas C, et al. Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin[J]. FASEB J, 2009, 23(1): 241-258.
[10] Peterson J M, Wei Z, Wong G W. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members[J]. Biochem Biophys Res Commun, 2009, 388(2): 360-365.
[11] Sun Y, Yi W, Yuan Y, et al. C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation[J]. Circulation, 2013, 128(26): 113-120.
[12] Peterson J M, Wei Z, Seldin M M, et al. CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction[J]. Am J Physiol Regul Integr Comp Physiol, 2013, 305(5): 522-533.
[13] Kambara T, Ohashi K, Shibata R, et al. CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism[J]. J Biol Chem, 2012, 287(23): 18965-18973.
[14] Uemura Y, Shibata R, Ohashi K, et al. Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell pro-liferation and neointimal formation[J]. FASEB J, 2013, 27(1): 25-33.
[15] Zheng Q, Yuan Y, Yi W, et al. C1q/TNF-related proteins, a family of novel adipokines, induce vascular re-laxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway[J]. Arterioscler Thromb Vasc Biol, 2011, 31(11): 2616-2623.
[16] Takeuchi S, Wada K, Uozumi Y, et al. Adiponectin receptor 1 expression is associated with carotid plaque stability[J]. Neurol India, 2013, 61(3): 249-253.
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