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山东大学学报 (医学版) ›› 2022, Vol. 60 ›› Issue (9): 19-23.doi: 10.6040/j.issn.1671-7554.0.2022.0874

• 生育力保护专题 • 上一篇    下一篇

。卵子冷冻保存现状与进展

马翔,赵飞燕   

  1. 南京医科大学第一附属医院生殖医学科 生殖医学国家重点实验室, 江苏 南京 210029
  • 发布日期:2022-09-02
  • 通讯作者: 马翔. E-mail:sxmaxiang@126.com
  • 基金资助:
    江苏省科技厅项目(BE2021743)

Status and progress of oocyte cryopreservation

MA Xiang, ZHAO Feiyan   

  1. State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Published:2022-09-02

摘要: 卵子冷冻保存至今已有30多年发展历史。卵子冷冻主要适用于肿瘤患者放化疗前、或非肿瘤患者和因个人因素延迟生育的人群可采用的生育力保存方式;此外还适用于因辅助生殖实施过程中,由于男方特殊的因素无法提供精子的一种补救方式。目前常用的卵子冷冻保存方式包括慢速冻存和玻璃化冻存,且随着技术的日趋成熟及对卵子保存的研究进展,玻璃化冷冻现已逐渐取代慢速程序化冷冻,成为一种成熟的生育力保存方式。目前大部分研究结果表明,使用冻存卵子与新鲜卵子进行胚胎移植,患者临床妊娠率、产科和围产期结局未见显著差异。

关键词: 卵子冷冻, 临床应用, 卵母细胞玻璃化冻存, 有效性, 安全性

Abstract: Oocyte cryopreservation has a history of more than 30 years, which is mainly applicable to the fertility preservation of cancer patients before radiotherapy and chemotherapy, or non-cancer patients and people who delay childbearing due to personal factors. In addition, it can also be used as a remedy for male inability to provide sperm due to special factors in the process of assisted reproduction. At present, the commonly used methods of oocyte cryopreservation include slow cryopreservation and vitrification cryopreservation, and with the progress of research, vitrification has gradually replaced slow cryopreservation. Many studies have shown no significant differences in clinical pregnancy rates, obstetric and perinatal outcomes between embryos transferred using frozen eggs and fresh eggs.

Key words: Egg freezing, Clinical application, Oocyte cryopreservation, Effectiveness, Safety

中图分类号: 

  • R711.6
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