山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (5): 116-120.doi: 10.6040/j.issn.1671-7554.0.2019.0148
• • 上一篇
贺婷婷1,刘红1,舒凯云1,宋晓翠2,石玉华1
HE Tingting1, LIU Hong1, SHU Kaiyun1, SONG Xiaocui2, SHI Yuhua1
摘要: 目的 探讨微小RNA-141(miR-141)在多囊卵巢综合征(PCOS)患者卵巢颗粒细胞中的表达,并评价其临床意义。 方法 选取70例PCOS患者,根据体质量指数(BMI)分为正常体质量组(BMI<25, n=42)和肥胖组(BMI≥25, n=28);选取同期71例对照患者,分为正常体质量组(BMI<25, n=60)和肥胖组(BMI≥25, n=11)。采用逆转录实时定量PCR(qRT-PCR)检测各组卵巢颗粒细胞中miR-141的表达,并分析其临床意义。 结果 PCOS正常体质量组中miR-141的表达高于对照正常体质量组(P<0.001);与对照肥胖组相比,miR-141在PCOS 肥胖组中高表达(P=0.009)。此外,PCOS患者妊娠并发症发生率有升高的趋势,但差异无统计学意义(P>0.0125)。 结论 PCOS患者正常体质量组与肥胖组中miR-141的表达水平分别高于其相对应的对照患者,且PCOS患者发生妊娠并发症的风险有升高的趋势,提示miR-141可能在PCOS的发病机制中发挥重要作用。
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