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山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (8): 14-19.doi: 10.6040/j.issn.1671-7554.0.2021.0825

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抗凝药物在反复不良妊娠治疗中的应用进展

张建平,罗莺儿   

  • 出版日期:2021-08-10 发布日期:2021-09-16
  • 通讯作者: 张建平. E-mail:zjp2570@126.com
  • 基金资助:
    国家重点研发计划(2019YFA0801403)

Application progress of anticoagulant drugs in the treatment of recurrent adverse pregnancy

ZHANG Jianping, LUO Yinger   

  1. Department of Obstetrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong, China
  • Online:2021-08-10 Published:2021-09-16

摘要: 不良妊娠主要包括自然流产、胎儿生长受限、子痫前期、早产以及羊水过少等。抗磷脂抗体综合征以及其他血栓前状态均可导致机体病理性血液高凝状态,引起以上各种妊娠并发症。抗凝药物以及抗血小板药物不仅可以抗凝,改善胎盘血流,还存在抗炎、抑制补体等调节滋养细胞功能的作用。因此,根据病因采取单独或联合的抗凝或抗血小板药物,在反复不良妊娠患者中应用广泛。论文对抗凝药物在反复不良妊娠中的应用进展进行综述。

关键词: 抗凝, 抗血小板, 不良妊娠, 胎盘介导, 妊娠并发症

Abstract: Adverse pregnancy includes spontaneous abortion, fetal growth restriction, preeclampsia, premature delivery, oligohydramnios, and so on. Antiphospholipid antibody syndrome and other prethrombotic states can lead to the bodys pathological hypercoagulable state, causing the above-mentioned complications. Anticoagulant and antiplatelet drugs can not only anticoagulate and improve placental blood flow, but also have anti-inflammatory and complement inhibition effects to regulate the function of trophoblasts. Therefore, single or combined anticoagulant or antiplatelet drugs are widely used in patients with recurrent adverse pregnancy. This article will review the application progress of anticoagulant drugs in recurrent adverse pregnancy.

Key words: Anticoagulant, Antiplatelet, Adverse pregnancy, Placenta-mediated, Pregnancy complications

中图分类号: 

  • R714.2
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