山东大学学报 (医学版) ›› 2017, Vol. 55 ›› Issue (12): 31-35.doi: 10.6040/j.issn.1671-7554.0.2017.861
王润梅1,2,杨秋红3,张芳1,4,马玉燕1
WANG Runmei1,2, YANG Qiuhong3, ZHANG Fang1,4, MA Yuyan1
摘要: 目的 探讨子痫前期患者远期预后及其后代妊娠时子痫前期发病风险。 方法 选择在临邑县人民医院健康体检部、济南市妇幼保健院查体中心、山东大学齐鲁医院健康体检中心查体有子痫前期病史的患者311例为研究组;选择同年龄组正常妊娠分娩的328例女性作为对照组,两组人群妊娠前均无高血压、糖尿病、肾脏疾病、心脑血管疾病及其他内科合并症病史。采用χ2检验比较两组人群发生高血压、心脑血管疾病等并发症,以及两组人群的女儿妊娠时罹患子痫前期情况。结果〓研究组患者发生高血压(23.79% vs 8.23%, P<0.001)、糖尿病(11.25% vs 6.71%, P=0.044)、微蛋白尿(21.54% vs 6.10%, P<0.001)、慢性肾脏病(10.29% vs 5.79%, P=0.036)、心力衰竭(2.57% vs 0.61%, P=0.046)及脑卒中(3.22% vs 0.91%, P=0.039)的概率均高于对照组,两组各远期预后指标比较差异均有统计学意义(P<0.05)。研究组患者的女儿妊娠时子痫前期发病率较无子痫前期家族史者明显升高(OR:5.35; 95%CI:2.20~12.97)。 结论 子痫前期患者远期发生心脑血管疾病的风险增加,其后代妊娠时发生子痫前期的风险也增加。
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