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山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (8): 38-43.doi: 10.6040/j.issn.1671-7554.0.2021.0935

• 生殖免疫的基础与临床研究进展专题 • 上一篇    下一篇

免疫抑制剂在风湿病相关复发性流产中的应用

国云飞,舒强*()   

  1. 山东大学齐鲁医院风湿科,山东 济南 250012
  • 收稿日期:2021-08-09 出版日期:2021-08-10 发布日期:2021-09-16
  • 通讯作者: 舒强 E-mail:shuqiang@sdu.edu.cn
  • 作者简介:舒强,博士,主任医师,博士研究生导师。山东大学齐鲁医院风湿科主任,主要从事类风湿关节炎、风湿病继发肺间质疾病、风湿病相关不良妊娠等研究,先后主持山东省自然科学基金、教育部留学基金委、横向项目等课题,获得山东科学技术进步奖三等奖、山东医学科技奖二等奖。在核心期刊和国际期刊发表论文30余篇。现任中国医师协会风湿免疫科医师分会、风湿病相关肺血管/间质病学组委员,山东省风湿病学分会副主任委员兼秘书,山东省医师协会风湿免疫学医师分会常委等职
  • 基金资助:
    山东大学临床研究中心急危重症重点专项经费(2021SDUCRCB010)

Role of immunosuppressants in rheumatic disease-associated recurrent spontaneous abortion

Yunfei GUO,Qiang SHU*()   

  1. Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2021-08-09 Online:2021-08-10 Published:2021-09-16
  • Contact: Qiang SHU E-mail:shuqiang@sdu.edu.cn

摘要:

复发性流产(RSA)的主要病因之一为合并风湿免疫病。近年来,免疫抑制剂在RSA合并风湿免疫病患者的治疗方案中逐渐占据主要地位,其治疗效果也普遍得到认可。由于RSA合并风湿免疫病涉及到多个学科领域,目前对于免疫抑制剂的适应证及用法用量亟待进一步规范。论文结合近年的临床指南和科学研究进展,从RSA定义、风湿病与RSA相关性、免疫抑制剂的使用等方面,对国内外现有文献进行述评,提高读者对于相关疾病及药物的认识,为临床医师在实践中做出合理决策提供参考。

关键词: 免疫抑制剂, 复发性流产, 风湿病, 类风湿关节炎, 系统性红斑狼疮, 结缔组织病

Abstract:

One of the main causes of recurrent spontaneous abortion (RSA) is the combination of rheumatologic diseases. In recent years, immunosuppressive agents have gradually taken the main role in the treatment of patients with RSA combined with rheumatologic diseases, and their therapeutic effects are generally recognized. Since RSA combined with rheumatic immune disease involves several disciplines, the indications and dosage of immunosuppressants need to be further standardized. In this paper, we review the existing domestic and international literature in terms of the definition of RSA, the correlation between rheumatic diseases and RSA, and the use of immunosuppressive drugs, in order to improve the readers' understanding of related diseases and drugs, and to provide reference for clinicians to make rational decisions in practice.

Key words: Immunosuppressants, Recurrent spontaneous abortion, Rheumatic diseases, Rheumatoid arthritis, Systemic lupus erythematosus, Connective tissue disease

中图分类号: 

  • R593.2
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