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山东大学学报 (医学版) ›› 2017, Vol. 55 ›› Issue (12): 24-30.doi: 10.6040/j.issn.1671-7554.0.2017.154

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雾化吸入及气管滴入阿米卡星、替加环素对健康小鼠支气管和肺组织的损伤

郑亮1,亓倩1,周玉法1,李玉2   

  1. 1.莱芜市人民医院呼吸内科, 山东 莱芜 271100;2.山东大学齐鲁医院呼吸内科, 山东 济南 250012
  • 出版日期:2017-12-20 发布日期:2022-09-27
  • 通讯作者: 周玉法. E-mail:lwsrmyyzyf@163.com李玉. E-mail:qlliyu@163.com
  • 基金资助:
    山东省科学技术发展计划(2012GSF11859)

Damage of bronchus and lung tissue in healthy mice after aerosol inhalation and intratracheal administration of amikacin and tigecycline

ZHENG Liang1, QI Qian1, ZHOU Yufa1, LI Yu2   

  1. 1. Department of Respiratory Disease, Laiwu City Peoples Hospital, Laiwu 271100, Shandong, China;
    2. Department of Respiratory Disease, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Online:2017-12-20 Published:2022-09-27

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摘要： 目的 探讨雾化吸入及气管滴入阿米卡星、替加环素对健康小鼠支气管和肺组织损伤的不同。 方法 将144只昆明种小白鼠随机分为9组(每组16只):空白对照组、生理盐水吸入组、阿米卡星低浓度吸入组、阿米卡星高浓度吸入组、替加环素低浓度吸入组、替加环素高浓度吸入组、生理盐水滴入组、阿米卡星滴入组及替加环素滴入组,各组给予相应处理,取各组小鼠支气管和肺组织两处的病理标本,比较各组小鼠支气管和肺泡损伤程度的不同。 结果 替加环素高浓度吸入组及阿米卡星高浓度吸入组小鼠的肺损伤程度评分均显著高于空白对照组(P=0.001;P<0.001)。阿米卡星高浓度吸入组小鼠的肺损伤程度评分显著高于生理盐水滴入组(P<0.001),亦显著高于替加环素滴入组(P=0.001)。 结论 无论雾化吸入还是气管内滴入均对小鼠肺组织有损伤,而雾化吸入阿米卡星对小鼠肺泡损伤程度高于气管滴入替加环素。

关键词: 雾化吸入, 气管滴注, 阿米卡星, 替加环素, 支气管, 肺组织, 损伤

Abstract: Objective To compare bronchus and lung tissue damage of healthy mice after aerosol inhalation and intratracheal administration of amikacin and tigecycline. Methods One hundred and forty-four Kunming species of mice were randomly divided into 9 groups(16 mice per group): blank control group, normal saline inhalation group, amikacin low concentration inhalation group, amikacin high concentration inhalation group, tigecycline low concentration inhalation group, tigecycline high concentration inhalation group, normal saline intratracheal administration group, amikacin intratracheal administration group and tigecycline intratracheal administration group. Each group was given the corresponding treatment. Then bronchus and lung tissue pathological specimens of each group of mice were obtained. The bronchus and lung tissue damage was compared among each group. Results Alveolar damage scores of tigecycline high concentration inhalation group and amikacin high concentration inhalation group were significantly higher than that of blank control group(P=0.001; P<0.001). Alveolar damage scores of amikacin high concentration inhalation group was significantly higher than that of normal saline intratracheal administration group(P<0.001)and tigecycline intratracheal administration group(P=0.001). Conclusion Alveolar might be damaged by aerosol inhalation or intratracheal 山 东 大 学 学 报 (医 学 版)55卷12期 -郑亮,等.雾化吸入及气管滴入阿米卡星、替加环素对健康小鼠支气管和肺组织的损伤 \=-administration of amikacin and tigecycline. The lung tissue damage after aerosol inhalation of amikacin might be more serious than intratracheal administration of tigecycline.

Key words: Aerosol inhalation, Intratracheal administration, Amikacin, Tigecycline, Bronchus, Lung tissue, Damage

中图分类号: 

  • R37
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