MR ASL灌注成像在足月新生儿缺氧缺血性脑病诊断中的应用

doi:10.6040/j.issn.1671-7554.0.2013.560

山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (2): 65-68.doi: 10.6040/j.issn.1671-7554.0.2013.560

MR ASL灌注成像在足月新生儿缺氧缺血性脑病诊断中的应用

孟琳琳1，王青1，李宜芳2，王芳1，王茜1，李文1，马祥兴1

1.山东大学齐鲁医院放射科，济南 250012； 2.日照市人民医院放射科，山东日照 276825

收稿日期:2013-09-13 出版日期:2014-02-10 发布日期:2014-02-10
通讯作者: 王青，E-mail:wangqing663@163.com
基金资助:
济南市科技计划高校院所自主创新项目（201202225）

Application of MR ASL perfusion weighted imaging in the diagnosis of full-term neonatal hypoxic ischemic encephalopathy

MENG Lin-lin1 , WANG Qing1, LI Yi-fang2, WANG Fang1, WANG Qian1, LI Wen1 , MA Xiang-xing1

1. Department of Radiology, Qilu Hospital of Shandong University， Jinan 250012， China;
2. Department of Radiology, Rizhao People′s Hospital, Rizhao 276825， Shandong, China

Received:2013-09-13 Online:2014-02-10 Published:2014-02-10

摘要/Abstract

摘要：

目的探讨动脉自旋标记（ASL）灌注加权成像在新生儿缺氧缺血性脑病（HIE）中的诊断价值。方法应用Siemens Magnetom Verio 3.0 T磁共振对42例经临床诊断的缺氧缺血性脑病足月新生儿（日龄1～15 d，HIE组）及20例无缺血缺氧史临床拟诊生理性高胆红素血症的足月新生儿（对照组）行常规序列及ASL技术检查，测量双侧额叶白质、丘脑、尾状核头部、豆状核的相对脑血流量（rCBF）值，比较两组之间不同部位rCBF值是否存在统计学差异；将HIE组根据检查时日龄不同分为1～3d、4～7d和8～15d 3个亚组，分析日龄对rCBF值的影响。结果 HIE组丘脑、豆状核的rCBF值较对照组明显升高（P均=0.01）；额叶白质rCBF值较对照组降低（P=0.02）；尾状核头部的rCBF与对照组无统计学差异（P=0.53）。1～3d亚组的HIE患儿感兴趣区rCBF值较其他亚组明显升高，差异有统计学意义（P均<0.05）。结论通过ASL技术测量rCBF有助于早期诊断HIE。

关键词: 新生儿, 磁共振, 缺氧缺血性脑病, 动脉自旋标记

Abstract:

Objective To explore the diagnostic value of arterial spin labeled (ASL) perfusion weighted imaging in full-term neonatal hypoxic ischemic encephalopathy(HIE). Methods The study was carried out in 42 full-term neonates (HIE group) who were clinically diagnosed as hypoxic ischemic encephalopathy(aged 1～15 days) . HIE group and 20 controls (control group) underwent routine magnetic resonance imaging scans (3.0T, Siemens Magnetom Verio,Germany)and ASL technology inspection. Relative cerebral blood flow (rCBF) values were measured in bilateral frontal white matter, thalamus, head of caudate nucleus and lentiform nucleus, followed by the comparasion of values of different parts between the two groups. HIE group was further divided into three subgroups which were 1 to 3 days, 4 to 7 days and 8 to 15 day according to the birth age. The influence of birth age on rCBF values was analyzed. Results rCBF values of thalamus and lentiform nucleus in HIE group increased significantly than those of control group (all P=0.01). rCBF values of frontal white matter in HIE group decreased than those of control group (P=0.02). There was no statistical difference in rCBF values of head of caudate nucleus between HIE group and control group (P=0.53). rCBF values of bilateral frontal white matter, thalamus, head of caudate nucleus and lentiform nucleus in the subgroup of 1 to 3 days were higher than those of the other two subgroups(all P<0.05). Conclusion It is helpful to make an early diagnosis of HIE by measuring rCBF values with ASL technology.

Key words: Hypoxic ischemic encephalopathy, Arterial spin labeled, Newborn, Magnetic resonance imaging

中图分类号:

R587.1

孟琳琳1，王青1，李宜芳2，王芳1，王茜1，李文1，马祥兴1. MR ASL灌注成像在足月新生儿缺氧缺血性脑病诊断中的应用[J]. 山东大学学报（医学版）, 2014, 52(2): 65-68.

MENG Lin-lin1,WANG Qing1, LI Yi-fang2, WANG Fang1, WANG Qian1, LI Wen1,MA Xiang-xing1. Application of MR ASL perfusion weighted imaging in the diagnosis of full-term neonatal hypoxic ischemic encephalopathy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(2): 65-68.

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MR ASL灌注成像在足月新生儿缺氧缺血性脑病诊断中的应用

Application of MR ASL perfusion weighted imaging in the diagnosis of full-term neonatal hypoxic ischemic encephalopathy

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