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山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (2): 69-72.doi: 10.6040/j.issn.1671-7554.0.2013.371

• 临床医学 • 上一篇    下一篇

高敏肌钙蛋白T在慢性心力衰竭患者中的变化及意义

陈东昌，谷颖，鹿克风   

  1. 山东大学附属省立医院心血管内科， 济南 250021
  • 收稿日期:2013-05-27 出版日期:2014-02-10 发布日期:2014-02-10
  • 通讯作者: 鹿克风， E-mail：lukefeng@medmail.com.cn
  • 基金资助:

    山东省自然科学基金(y2007c080)；山东省卫生厅科研基金(2007HZ067)

Changes of serum high sensitivity of troponin T concentration and its clinical significance in chronic heart failure

CHEN Dong-chang, GU Ying, LU Ke-feng   

  1. Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2013-05-27 Online:2014-02-10 Published:2014-02-10

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摘要：

目的  探讨高敏肌钙蛋白T(hs-cTnT)在慢性心力衰竭(CHF)患者中的变化及其意义。方法   选取慢性心力衰竭患者147例(心衰组)，依据心功能分级将其分为4个亚组；同时选取健康查体者30例(对照组)。空腹采血检测血清hs-cTnT及血浆N末端脑钠肽(NT-proBNP)浓度，并行超声心动图检查。结果   ①心衰组较对照组hs-cTnT浓度显著升高(P<0.05)；心衰各亚组间hs-cTnT差异均有统计学意义(P均<0.05)，且随心功能分级增加而升高(P<0.05)；心衰亚组Ⅰ组较对照组hs-cTnT浓度升高(P<0.05)。心衰组与对照组超声心动图参数、NT-proBNP浓度差异有统计学意义(P<0.05)；心衰各亚组之间超声心动图参数、NT-proBNP浓度差异有统计学意义(P<0.05)。②心衰组Log hs-cTnT与Log NT-proBNP、LAd、LVEDd呈正相关(r分别为：0.680，0.345，0.326，P均<0.05)，与LVEF呈负相关(r=-0.551，P<0.05)。结论    慢性心力衰竭患者无论有无心衰症状，血清hs-cTnT均升高，并与心衰程度及NT-proBNP呈正相关，hs-cTnT能较好反映慢性心衰患者的心功能状态。

关键词: 高敏肌钙蛋白T, 心功能, N末端脑钠肽

Abstract:

Objective   To investigate the changes and clinical significance of the concentration of serum high sensitivity of cardiac troponin T (hs-cTnT) in chronic heart failure (CHF).  Methods  A total of 147 patients with chronic heart failure were enrolled in the chronic heart failure group (CHF group), which was divided into 4 subgroups, and 30 healthy Objective   s were controls. The cardiac function of the patients was evaluated according to the standard of American New York Heart Association (NYHA). The blood samples of all patients and controls were collected, the concentrations of serum hs-cTnT and NT-proBNP were detected, and echocardiography was performed. Results  ① The concentration of serum hs-cTnT of the CHF group were higher than that of the control group (P<0.05). The concentrations of serum hs-cTnT were obviously different among the subgroups (P<0.05), and the worse the cardiac function was, the higher the serum hs-cTnT was. The echocardiographic parameters and NT-proBNP concentration of the CHF group and control group were statistically different (P<0.05). The echocardiographic parameters and NT-proBNP concentration of the subgroups of the CHF group were statistically different (P<0.05). ② Serum hs-cTnT of the CHF group was positively correlated with NT-proBNP, LAd, and LVEDd (r=0.680, 0.345 and 0.326, P<0.05), and negatively correlated with LVEF (r=-0.551, P<0.05). Conclusion  The concentration of the serum hs-cTnT is elevated and positively correlated to the severity of heart failure and concentration of plasma NT-proBNP, which can reflect patients’ cardiac function.

Key words: Chronic heart failure, High sensitivity of cardiac troponin T, NT-proBNP

中图分类号: 

  • R541
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