您的位置：山东大学 -> 科技期刊社 -> 《山东大学学报（医学版）》

山东大学学报（医学版） ›› 2017, Vol. 55 ›› Issue (10): 84-89.doi: 10.6040/j.issn.1671-7554.0.2017.167

• 临床医学 • 上一篇    下一篇

B类I型清道夫受体的高表达与结肠癌患者预后的相关性

刘惠苓1,王兴文1,冯少滨2,冯虹1,韩俊庆1   

  1. 1.山东大学附属省立医院肿瘤治疗中心;2.山东大学附属省立医院神经外科, 山东 济南 250021
  • 收稿日期:2017-02-23 出版日期:2017-10-10 发布日期:2017-10-10
  • 通讯作者: 韩俊庆. E-mail:hanjunqing1960@126.com冯虹. E-mail:fenghong1268@hotmail.com E-mail:hanjunqing1960@126.com
  • 基金资助:
    国家自然科学基金(81201865)

Association between high expression of scavenger receptor class B type I and the prognosis of colon cancer

LIU Huiling1, WANG Xingwen1, FENG Shaobin2, FENG Hong1, HAN Junqing1   

  1. 1. Cancer Center, Shandong Provincial Hospital Affiliated of Shandong University;
    2. Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2017-02-23 Online:2017-10-10 Published:2017-10-10

PDF (PC)

259

摘要： 目的 分析B类I型清道夫受体(SR-BI)的表达与结肠癌患者各临床病理变量之间的关系,并探讨SR-BI的表达状态与患者的预后关系,以期寻找新的结肠癌预后指标和潜在的治疗靶点。 方法 采用免疫组织化学染色方法对购自上海芯超生物科技有限公司的含90例结肠癌组织和相对应的癌旁组织的芯片进行SR-BI表达的检测,并分析其与结肠癌的发生发展、临床病理特征及患者预后的关系。 结果 SR-BI在78.9%的结肠癌组织比相对应的癌旁组织表达高(P<0.001),SR-BI的表达水平与临床病理特征无关。在结肠癌组织中,SR-BI低表达的患者比SR-BI高表达的患者总体生存率(OS)缩短(P=0.042)。Cox回归多因素分析提示SR-BI的高表达是影响预后的独立有利因素(P=0.039)。 结论 SR-BI表达水平越低,结肠癌患者预后越差。结肠癌组织中SR-BI的表达水平是结肠癌患者的独立预后因素。

关键词: B类I型清道夫受体, 预后, 结肠癌, 免疫组织化学

Abstract: Objective To explore the association between the expression of scavenger receptor class B type I(SR-BI)and the clinicopathological variables, and to determine whether SR-BI expression was an independent prognostic factor and a potential therapeutic target for colon cancer. Methods A well-documented tissue microarray of 90 patients with colon cancer was purchased from Shanghai Outdo Biotech Co., Ltd. The SR-BI expression in the cancer tissues and para-cancerous tissues were detected with immunohistochemical method. The association between SR-BI expression and the clinicopathological variables, and patients outcome was analyzed. Results In 78.9% of the cases, SR-BI expression was higher in the cancer tissues than in the adjacent non-tumor tissues(P<0.001). The expression of SR-BI in colon cancer tissues had no significant statistical association with the clinicopathological variables. Patients with low SR-BI expression in colon cancer tissues had a shorter overall survival(OS)than those with high SR-BI expression(P=0.042). The multivariate analysis confirmed that high SR-BI expression was an independent favorable prognostic factor for OS(P=0.039). Conclusion Low SR-BI expression is associated with unfavorable prognosis of colon cancer. SR-BI is an independent prognostic factor of colon cancer.

Key words: Colon cancer, Prognosis, Scavenger receptor class B type I, Immunohistochemistry

中图分类号: 

  • R735.3
[1] Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015 [J]. CA Cancer J Clin, 2016, 66(2):115-132.
[2] Vargas AJ, Thompson PA. Diet and nutrient factors in colorectal cancer risk [J]. Nutr Clin Pract, 2012, 27(5): 613-623.
[3] Barone M, Lofano K, De Tullio N, et al. Dietary, endocrine and metabolic factors in the development of colorectal cancer [J]. J Gastrointest Cancer, 2012, 43(1): 13-19.
[4] Ruder EH, Thiebaut AC, Thompson FE, et al. Adolescent and mid-life diet: risk of colorectal cancer in the NIH-AARP diet and health study [J]. Am J Clin Nutr, 2011, 94(6):1607-1619.
[5] Liao F, He W, Xia L, et al. A high LDL-C to HDL-C ratio predicts poor prognosis for initially metastatic colorectal cancer patients with elevations in LDL-C [J]. Onco Targets Ther, 2015, 8: 3135-3142. doi: 10.2147/OTT.S90479.
[6] Shen WJ, Hu J, Salman Azhar, et al. Scavenger receptor class B type I(SR-BI): a versatile receptor with multiple functions and actions [J]. Metabolism, 2014, 63(7): 875-886.
[7] Pelton K, Freeman MR, Solomon KR. Cholesterol and prostate cancer [J]. Curr Opin Pharmacol, 2012, 12(6): 751-759.
[8] 李文燕, 刘洪涛, 王瑞芝. B 类Ⅰ型清道夫受体SR-BI表达上调剂的研究进展[J]. 沈阳药科大学学报, 2016, 33(6): 507-511.
[9] Danilo C, Gutierrez-Pajares JL, Frank PG, et al. Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development [J]. Breast Cancer Res, 2013, 15(5): R87.
[10] Zheng Y, Liu Y, Zhang Z, et al. Scavenger receptor B1 is a potential biomarker of human nasopharyngeal carcinoma and its growth is inhibited by high-density lipoprotein-mimetic nanoparticles [J]. Theranostics, 2013, 3(7):477-486.
[11] Muntoni S, Atzori L, Mereu R, et al. Serum lipoproteins and cancer [J]. Nutr Metab Cardiovasc Dis, 2009, 19(3): 218-225.
[12] Jacobs EJ, Stevens VL, Gapstur SM, et al. Plasma total, LDL, and high-density lipoproteincholesterol and risk of aggressive prostate cancer in the Cancer Prevention Study II Nutrition Cohort [J]. Cancer Causes Control, 2012, 23(8): 1289-1296.
[13] Cruz P, Mo H, Lacko A, et al. The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics[J]. Front Pharmacol, 2013, 4(119): 3389-3396.
[14] Huang LZ, Gao JL, Zhang Y, et al. Apolipoprotein M: research progress, regulation and metabolic functions [J]. Mol Med Rep, 2015, 12(2): 1617-1624.
[15] Yao X, Tian Z. Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective studies [J]. Cancer Causes Control, 2015, 26(2): 257-268.
[16] Davis Yadley AH, Lipka S, Pan Q, et al. Ethnic disparities in the risk of colorectal adenomas associated with lipid levels: a retrospective multiethnic study [J]. J Gastrointest Cancer, 2015, 46(1): 29-35.
[17] Zhang X, Zhao XW, Wang Y, et al. Lipid levels in serum and cancerous tissues of colorectal cancer patients [J]. World J Gastroenterol, 2014, 20(26): 8646-8652.
[18] Borgquist S, Butt T, Melander O, et al. Apolipoproteins, lipids and risk of cancer[J]. Int J Cancer, 2016, 138(11): 2648-2656.
[19] Chandler PD, Song Y, Ridker PM, et al. Lipid biomarkers and long-term risk of cancer in the Womens Health Study [J]. Am J Clin Nutr, 2016, 103(6): 1397-1407.
[20] Coppola JA, Shrubsole MJ, Murff HJ, et al. Plasma lipid levels and colorectal adenoma risk [J]. Cancer Causes Control, 2015, 26(4):635-643.
[21] Wang Y, Wang ZQ, Li YH, et al. Predictive value of chemotherapy-related high-density lipoprotein cholesterol(HDL)elevation in patients with colorectal cancer receiving adjuvant chemotherapy: an exploratory analysis of 851 cases [J]. Oncotarget, 2016, 7(35):57290-57300.
[22] 李传凤,李军,白鹏,等.结直肠腺瘤与患者血脂代谢水平[J]. 北京大学学报(医学版),2011,43(3):432-435. LI Chuanfeng, LI Jun, BAI Peng, et al. Characteristic analysis of plasma lipid metabolism level in patients withcolorectal adenoma[J]. Journal of Peking University(Health Science), 2011, 43(3): 432-435.
[23] 申光哲, 金头峰. 结直肠癌与代谢综合征的相关性[J]. 延边大学医学学报, 2015, 38(1): 25-27.
[24] Cruz PM, Mo H, McConathy WJ, et al. The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics [J]. Front Pharmacol, 2013, 4: 119. doi: 10.3389/fphar.2013.00119.
[25] Su F, Grijalva V, Navab K, et al. HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer [J]. Mol Cancer Ther, 2012, 11(6): 1311-1319.
[1] 黄方 康瑞 吴春林. VEGFC、NF-κBp65及Survivin在鼻咽癌中的表达及临床意义[J]. 山东大学学报(医学版), 2209, 47(6): 83-.
[2] 李梓绮,魏闫若雪,刘晓晗,刘春铖,赵然,刘玉昆. 长链非编码RNA HEATR3反义RNA 1参与结直肠癌发生发展的功能及其临床意义[J]. 山东大学学报 (医学版), 2025, 63(9): 108-115.
[3] 刘保国,宋翔,赵晓文,毛亚丽. 血清STAT5B、NKAIN1 mRNA检测在乳腺癌中的应用价值[J]. 山东大学学报 (医学版), 2025, 63(7): 68-74.
[4] 王磊,常霄,王梓萌,李娇娇,崔书君,杨飞,朱月香. 瘤内及瘤周DCE-MRI影像组学对宫颈癌患者无进展生存期的预测价值[J]. 山东大学学报 (医学版), 2025, 63(6): 45-54.
[5] 贾若曦,吕丽,刘涵云,吴寅平,李凤彩,赵泽华,王凯,范玉琛. 血细胞计数相关标志物对慢加急性乙型肝炎肝衰竭患者28天预后的诊断价值[J]. 山东大学学报 (医学版), 2025, 63(6): 89-99.
[6] 杜雪,李春霞,刘云霞,张涛. 基于MFPC-Cox的结直肠癌患者预后动态预测模型[J]. 山东大学学报 (医学版), 2025, 63(5): 101-110.
[7] 杨卫芳,徐宏,刘元涛,赵蕙琛. 促甲状腺激素受体抗体在Graves病复发中的作用机制及其临床意义[J]. 山东大学学报 (医学版), 2025, 63(4): 116-121.
[8] 刘文钊,张远,马湘萍,魏峰涛,卜培莉. 内皮活化和应激指数预测值与心力衰竭患者死亡风险的关联[J]. 山东大学学报 (医学版), 2025, 63(11): 27-35.
[9] 陈文亮,王欢欢,郝金锦,弓蕊,赵强,张飞,高磊,董静逊. lncRNA PVT1表达在胃癌预后评估及恶性进展中的作用:基于列线图模型与细胞功能实验的研究[J]. 山东大学学报 (医学版), 2025, 63(10): 61-71.
[10] 郭姝画,樊扬,田风,王传新,杜鲁涛,李培龙,郭兴,徐硕. 微原纤维相关蛋白3在调控胶质瘤干细胞间充质表型转化中的作用[J]. 山东大学学报 (医学版), 2024, 62(6): 9-16.
[11] 魏闫若雪,李梓绮,刘春铖,刘晓晗,赵然,刘玉昆. 结直肠癌中SP1的瘤内异质性表达及其临床意义[J]. 山东大学学报 (医学版), 2024, 62(5): 89-94.
[12] 吴霖,石晨曦,童星. 肺良性转移性平滑肌瘤病7例并文献复习[J]. 山东大学学报 (医学版), 2024, 62(4): 78-84.
[13] 刘爱静,李雁儒,高惠茹,段伟丽,李培龙,李娟,杜鲁涛,王传新. 自噬相关蛋白5在结肠癌中的表达及对结肠癌细胞迁移及侵袭能力的影响[J]. 山东大学学报 (医学版), 2024, 62(4): 14-23.
[14] 刘春铖,刘晓晗,魏闫若雪,李梓绮,刘玉昆,赵然. 结直肠癌中含溴结构域蛋白9的亚细胞定位模式及其临床意义[J]. 山东大学学报 (医学版), 2024, 62(4): 24-30.
[15] 杨雪彦,吴寅平,吕丽,赵泽华,马行宇,李凤彩,王凯,范玉琛. 单核细胞与淋巴细胞比值动态变化对慢加急性乙型肝炎肝衰竭预后的诊断价值[J]. 山东大学学报 (医学版), 2024, 62(3): 61-69.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
版权所有 © 2018 《山东大学学报(医学版)》编辑部　
地址:山东大学科技期刊社（济南市历城区山大南路27号山东大学中心校区明德楼B座721室） 电话: 0531-88366918 E-mail: xbyxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发