JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Ursolic acid inhibits the angiogenesis of transplanted human lung adenocarcinoma cell line A549 in nude mice

LI Xi-bo, SUN Xue-fei, YIN Qiu-wei, WANG De-jiang   

  1. Department of Thoracic Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China
  • Received:2006-12-20 Revised:1900-01-01 Online:2007-02-24 Published:2007-02-24
  • Contact: LI Xi-bo

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Abstract: Objective： To study the inhibitory effect of ursolic acid on the transplanted human lung adenocarcinoma cell line A549 in nude mice and explore its mechanism. Methods： The nude mice bearing A549 cancer cells were established in vivo. The transplanted tumor growth curve was drawn, and the inhibitive ratio was calculated according to tumor weight. Immunohistochemistry (S-P)was used to examine the expression of VEGF and MVD of the transplanted tumor, and TUNEL (Terminal deoxynucleotidyl transferase mediated UTP nick end labeling) was used to examine the apoptosis index of the transplanted tumor. Results： The transplanted tumor of the treated group grew slowly. The volume and the weight of tumors in the treated group were smaller than those in the control group. The tumor inhibitive rate was 51.35％. The expressions of VEGF and MVD in the treated group were lower than those of the control group, and the apoptosis index of the transplanted tumor in the treated group was higher than that in the control group(P＜0.01). Conclusion： Ursolic acid has an anti-angiogenesis activity on the human lung adenocarcinoma cell line A549 in vivo by inducing the apoptosis of the cancer cells, deceasing the VEGF expression and inhibiting the vasoformation of the transplanted tumor.

Key words: Lung cancer, Apoptosis, Angiogenesis, Ursolic acid

CLC Number: 

  • R734.2
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