Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (12): 43-48.doi: 10.6040/j.issn.1671-7554.0.2024.0174

• Clinical Pharmaceutical Research and Evaluation • Previous Articles    

Pharmaceutical characteristics and clinical utility of dipeptidyl peptidase-4 inhibitors

LIN Xiaoqian*, FENG Maoyan*, MOU Zheng   

  1. Department of Pharmacy, Qilu Hospital(Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266035, Shandong, China
  • Published:2024-12-09

Abstract: Diabetes mellitus is a global public health problem, which leads to enormous human suffering. The prevalence of type 2 diabetes mellitus(T2DM)remains rising in China. Meanwhile, the awareness and control rate of diabetes have increased, but they are still at a low level. Dipeptidyl peptidase-4(DPP-4)inhibitors are novel oral antihyperglycemic agents. The unique mechanism of DPP-4 inhibitors satisfy different clinical demands. However, the molecular structure, clinical application and safety information of available DPP-4 inhibitors are different. We focus specially on the different clinical pharmaceutical characters, efficacy, safety and application on special population of DPP-4 inhibitors, which aims to provide the best drugs for individual patients.

Key words: Diabetes mellitus, Dipeptidyl peptidase-4 inhibitors, Pharmaceutical characteristics, Clinical application, Drug safety

CLC Number: 

  • R587.1
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