Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (12): 38-42.doi: 10.6040/j.issn.1671-7554.0.2024.0111

• Clinical Pharmaceutical Research and Evaluation • Previous Articles    

Current status of drug clinical research for the treatment of chronic rhinosinusitis with nasal polyps in China

CAO Yuan1, ZHANG Jianqiao1, MENG Xiangwei1, LIU Wen2, PANG Xiaoming1   

  1. 1. Drug Clinical Trial Institution;
    2. Department of Rhinology, Zibo Central Hospital, Zibo 255000, Shandong, China
  • Published:2024-12-09

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Abstract: The clinical manifestations of chronic rhinosinusitis(CRS)are chronic nasal congestion, runny nose, and loss of sense of smell, which seriously affect the patients quality of life. The pathogenesis of CRS is highly heterogeneous, and the phenotype associated with nasal polyps is chronic rhinosinusitis with nasal polyps(CRSwNP). Clinical trials of various biological agents targeting intrinsic biomarkers have been conducted to address the limited efficacy of traditional treatment drugs and postoperative recurrence in patients with CRSwNP. In recent years, clinical research for the treatment of CRSwNP in China has flourished, and self-developed varieties of domestic enterprises continue to emerge, bringing new choices for CRSwNP patients, especially those with severe and refractory CRSwNP. By summarizing the current status and development trends of clinical research for the treatment of CRSwNP in China, this study aims to provide information and reference for the research and development of drugs for treating CRSwNP.

Key words: Chronic rhinosinusitis, Nasal polyps, Targeted drug, Clinical trials

CLC Number: 

  • R97
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