Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (12): 52-57.doi: 10.6040/j.issn.1671-7554.0.2022.0252

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Inflammatory characteristics of lobar pneumonia in children with exact pathogens

XIE Xinyi1,2, ZHANG Amin1, ZHENG Wenyu1,2, NING Haonan1,2, YAN Xiankang1,2, MA Chenhui1,2, LI Fuhai1   

  1. 1.Department of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2022-12-01

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Abstract: Objective To explore the inflammatory characteristics of lobar pneumonia in children based on accurate etiology. Methods The clinical data of 153 children with lobar pneumonia hospitalized in the Department of Pediatrics, Qilu Hospital of Shandong University during June 2021 and December 2021 were retrospectively analyzed. According to the detection results of metagenomic next-generation sequencing(mNGS)of the bronchoalveolar lavage fluid(BALF), the single infection group was infected with mycoplasma pneumoniae(MP)(n=52), and the mixed infection group was infected with streptococcus pneumoniae(SP)and MP(n=26). Results MP was detected in the BALF of 133 cases(86.9%). The neutrophil and neutrophil to lymphocyte ratio in the single infection group were significantly higher than those in the mixed infection group(Z=-2.411, P=0.016; Z=-2.025, P=0.043). The number of leukocytes in the two groups 8 days before the onset of disease was significantly lower than that 8 days after the onset(Z=-2.399, P=0.016; Z=-2.109, P=0.035). The cells in BALF were mainly neutrophils. There was no significance in the numbers of neutrophils and macrophages 8 days before and after the onset of disease in the single infection group(t=1.334, P=0.190; t=-0.082, P=0.935). In the mixed infection group, the number of neutrophils 8 days before onset was significantly higher than that 8 days after onset, while the number of macrophages was significantly lower(t=2.707, P=0.025; t=-6.087, P<0.001). Conclusion Lobar pneumonia in children is mostly mixed infection caused by MP and SP, with strong local and systemic inflammatory response. There are frequently refractory cases.

Key words: Lobar pneumonia, Mycoplasma pneumoniae, Streptococcus pneumoniae, Immunoregulation, Children

CLC Number: 

  • R725.6
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